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제1기 비소세포폐암에서 APT1 발현의 임상적 의미

Other Titles
 The Clinical and Pathologic Features according to Expression of Acyl Protein Thioesterase-1 (APT1) in Stage I Non-small Cell Lung Cancer 
Authors
 신정아  ;  이창률  ;  변민광  ;  장윤수  ;  김세규  ;  장 준  ;  안철민  ;  김형중 
Citation
 Tuberculosis and Respiratory Diseases, Vol.68(4) : 212-217, 2010 
Journal Title
 Tuberculosis and Respiratory Diseases 
ISSN
 3780-0066 
Issue Date
2010
MeSH
Apoptosis ; Biomarkers, Tumor ; Carcinoma, Hepatocellular/blood* ; Carcinoma, Hepatocellular/metabolism* ; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis* ; Cyclin-Dependent Kinase Inhibitor p16/genetics* ; DNA Methylation* ; Humans ; Liver/metabolism ; Liver Neoplasms/blood* ; Liver Neoplasms/metabolism* ; Neoplasm Metastasis ; Polymerase Chain Reaction ; Promoter Regions, Genetic ; Sulfites/pharmacology ; Time Factors
Abstract
BACKGROUND: Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. METHODS: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. RESULTS: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. CONCLUSION: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.
Files in This Item:
T201001071.pdf Download
DOI
10.4046/trd.2010.68.4.212
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
Shin, Jung Ar(신정아)
Ahn, Chul Min(안철민)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100950
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