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Timing of prepubertal androgen administration may have different effects on future fertility as well as penile size in normal male rats

 Hyeyoung Lee  ;  Mei Hua Jin  ;  Hyo Jin Kang  ;  Chang Hee Hong  ;  Woo Jin Bang  ;  Kyung Ki Park  ;  Sang Won Han 
 UROLOGY, Vol.75(4) : 979-984, 2010 
Journal Title
Issue Date
Age Factors ; Androgens/administration & dosage* ; Animals ; Fertility/drug effects* ; Male ; Penis/anatomy & histology* ; Penis/drug effects* ; Rats ; Rats, Sprague-Dawley ; Sexual Maturation* ; Testosterone/administration & dosage ; Testosterone/analogs & derivatives*
OBJECTIVES: To investigate the effects of androgen administration at different periods of prepubertal life on penile size and potential fertility in hormonally normal rats.

METHODS: Eighty Sprague-Dawley rats were divided into 4 groups; group 1 received weekly injections of testosterone enanthate (8 mg/100 g) at 1-3 weeks group 2 at 3-5 weeks, group 3 at 1-5 weeks, and group 4 was control (n = 20 each). Animals were killed at age 60 days. Penile length, penile, testicular, and epididymal weight, testicular fertility index, serum follicular stimulating hormone, luteinizing hormone, and testosterone levels were measured and quantitative real time polymerase chain reaction of penile androgen receptor messenger ribonucleic acids was performed.

RESULTS: Penile length in the 3-5-week injection group was significantly longer than controls (41.18 vs 39.13 mm, P = .011), and it was smaller than controls in the 1-3 week injection group (37.24 vs 39.13 mm, P = .020). The penile wet weight showed a similar pattern to stretched penile length; however, statistical significance was not found. Testicular weight was significantly less in the testosterone injection group than controls (1.79, 2.16, 2.24, and 2.78 g in groups 1-4, respectively) as well as the epididymal weight (0.48, 0.42, 0.59, and 0.69 in groups 1-4, respectively). The mean tubular diameter and germ cell count were significantly reduced in the testosterone treated group. Total penile androgen receptor messenger ribonucleic acid level was significantly lower in group 3 as compared with controls.

CONCLUSIONS: Testosterone administered during early prepubertal life resulted in smaller penis than controls, as well as having an adverse effect on testicular development which can jeopardize potential fertility.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Hyo Jin(강효진)
Park, Kyung Kgi(박경기)
Lee, Hye Young(이혜영)
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
Hong, Chang Hee(홍창희) ORCID logo https://orcid.org/0000-0002-0946-7702
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