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Timing of prepubertal androgen administration may have different effects on future fertility as well as penile size in normal male rats

DC FieldValueLanguage
dc.contributor.author강효진-
dc.contributor.author박경기-
dc.contributor.author이혜영-
dc.contributor.author한상원-
dc.contributor.author홍창희-
dc.date.accessioned2015-04-23T16:36:10Z-
dc.date.available2015-04-23T16:36:10Z-
dc.date.issued2010-
dc.identifier.issn0090-4295-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100882-
dc.description.abstractOBJECTIVES: To investigate the effects of androgen administration at different periods of prepubertal life on penile size and potential fertility in hormonally normal rats. METHODS: Eighty Sprague-Dawley rats were divided into 4 groups; group 1 received weekly injections of testosterone enanthate (8 mg/100 g) at 1-3 weeks group 2 at 3-5 weeks, group 3 at 1-5 weeks, and group 4 was control (n = 20 each). Animals were killed at age 60 days. Penile length, penile, testicular, and epididymal weight, testicular fertility index, serum follicular stimulating hormone, luteinizing hormone, and testosterone levels were measured and quantitative real time polymerase chain reaction of penile androgen receptor messenger ribonucleic acids was performed. RESULTS: Penile length in the 3-5-week injection group was significantly longer than controls (41.18 vs 39.13 mm, P = .011), and it was smaller than controls in the 1-3 week injection group (37.24 vs 39.13 mm, P = .020). The penile wet weight showed a similar pattern to stretched penile length; however, statistical significance was not found. Testicular weight was significantly less in the testosterone injection group than controls (1.79, 2.16, 2.24, and 2.78 g in groups 1-4, respectively) as well as the epididymal weight (0.48, 0.42, 0.59, and 0.69 in groups 1-4, respectively). The mean tubular diameter and germ cell count were significantly reduced in the testosterone treated group. Total penile androgen receptor messenger ribonucleic acid level was significantly lower in group 3 as compared with controls. CONCLUSIONS: Testosterone administered during early prepubertal life resulted in smaller penis than controls, as well as having an adverse effect on testicular development which can jeopardize potential fertility.-
dc.description.statementOfResponsibilityopen-
dc.format.extent979~984-
dc.relation.isPartOfUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Factors-
dc.subject.MESHAndrogens/administration & dosage*-
dc.subject.MESHAnimals-
dc.subject.MESHFertility/drug effects*-
dc.subject.MESHMale-
dc.subject.MESHPenis/anatomy & histology*-
dc.subject.MESHPenis/drug effects*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSexual Maturation*-
dc.subject.MESHTestosterone/administration & dosage-
dc.subject.MESHTestosterone/analogs & derivatives*-
dc.titleTiming of prepubertal androgen administration may have different effects on future fertility as well as penile size in normal male rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorHyeyoung Lee-
dc.contributor.googleauthorMei Hua Jin-
dc.contributor.googleauthorHyo Jin Kang-
dc.contributor.googleauthorChang Hee Hong-
dc.contributor.googleauthorWoo Jin Bang-
dc.contributor.googleauthorKyung Ki Park-
dc.contributor.googleauthorSang Won Han-
dc.identifier.doi10.1016/j.urology.2009.08.064-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04285-
dc.contributor.localIdA03316-
dc.contributor.localIdA00101-
dc.contributor.localIdA01419-
dc.contributor.localIdA04447-
dc.relation.journalcodeJ02775-
dc.identifier.eissn1527-9995-
dc.identifier.pmid19896173-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0090429509025060-
dc.contributor.alternativeNameKang, Hyo Jin-
dc.contributor.alternativeNamePark, Kyung Kgi-
dc.contributor.alternativeNameLee, Hye Young-
dc.contributor.alternativeNameHan, Sang Won-
dc.contributor.alternativeNameHong, Chang Hee-
dc.contributor.affiliatedAuthorHan, Sang Won-
dc.contributor.affiliatedAuthorLee, Hye Young-
dc.contributor.affiliatedAuthorKang, Hyo Jin-
dc.contributor.affiliatedAuthorPark, Kyung Kgi-
dc.contributor.affiliatedAuthorHong, Chang Hee-
dc.citation.volume75-
dc.citation.number4-
dc.citation.startPage979-
dc.citation.endPage984-
dc.identifier.bibliographicCitationUROLOGY, Vol.75(4) : 979-984, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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