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Phase-sensitive, dual-acquisition, single-slab, 3D, turbo-spin-echo pulse sequence for simultaneous T2-weighted and fluid-attenuated whole-brain imaging

Authors
 Jaeseok Park  ;  Suhyung Park  ;  Eung Yeop Kim  ;  Jin-Suck Suh 
Citation
 MAGNETIC RESONANCE IN MEDICINE, Vol.63(5) : 1422-1430, 2010 
Journal Title
MAGNETIC RESONANCE IN MEDICINE
ISSN
 0740-3194 
Issue Date
2010
MeSH
Algorithms* ; Brain/anatomy & histology* ; Cerebrospinal Fluid/cytology* ; Humans ; Image Enhancement/methods* ; Image Interpretation, Computer-Assisted/methods* ; Magnetic Resonance Imaging/methods* ; Reproducibility of Results ; Sensitivity and Specificity ; Spin Labels ; Subtraction Technique*
Keywords
magnetic resonance imaging ; MRI ; fluid- attenuated ; three-dimensional ; variable flip angle ; spin echo ; phase-sensitive
Abstract
Conventional T(2)-weighted turbo/fast spin echo imaging is clinically accepted as the most sensitive method to detect brain lesions but generates a high signal intensity of cerebrospinal fluid (CSF), yielding diagnostic ambiguity for lesions close to CSF. Fluid-attenuated inversion recovery can be an alternative, selectively eliminating CSF signals. However, a long time of inversion, which is required for CSF suppression, increases imaging time substantially and thereby limits spatial resolution. The purpose of this work is to develop a phase-sensitive, dual-acquisition, single-slab, three-dimensional, turbo/fast spin echo imaging, simultaneously achieving both conventional T(2)-weighted and fluid-attenuated inversion recovery-like high-resolution whole-brain images in a single pulse sequence, without an apparent increase of imaging time. Dual acquisition in each time of repetition is performed, wherein an in phase between CSF and brain tissues is achieved in the first acquisition, while an opposed phase, which is established by a sequence of a long refocusing pulse train with variable flip angles, a composite flip-down restore pulse train, and a short time of delay, is attained in the second acquisition. A CSF-suppressed image is then reconstructed by weighted averaging the in- and opposed-phase images. Numerical simulations and in vivo experiments are performed, demonstrating that this single pulse sequence may replace both conventional T(2)-weighted imaging and fluid-attenuated inversion recovery
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mrm.22317/abstract
DOI
10.1002/mrm.22317
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Yeop(김응엽)
Park, Jae Seok(박재석)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100864
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