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Prognosis for craniofacial fibrous dysplasia after incomplete resection: age and serum alkaline phosphatase

Authors
 B.Y. Park  ;  Y.W. Cheon  ;  Y.O. Kim  ;  N.S. Pae  ;  W.J. Lee 
Citation
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.39(3) : 221-226, 2010 
Journal Title
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 
ISSN
 0901-5027 
Issue Date
2010
MeSH
Adolescent ; Adult ; Age Factors ; Alkaline Phosphatase/blood* ; Biomarkers/blood ; Bone Transplantation ; Child ; Disease Progression ; Facial Bones/surgery* ; Female ; Fibrous Dysplasia, Monostotic/blood ; Fibrous Dysplasia, Monostotic/surgery ; Fibrous Dysplasia, Polyostotic/blood ; Fibrous Dysplasia, Polyostotic/surgery* ; Follow-Up Studies ; Forecasting ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Osteotomy/methods ; Prognosis ; Recurrence ; Remission Induction ; Retrospective Studies ; Skull Base/surgery* ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
Keywords
craniofacial fibrous dysplasia ; incomplete resection ; age ; alkaline phosphatase ; prognostic factor
Abstract
Complete resection is usually impossible for fibrous dysplasia (FD) involving the cranial base. Incomplete resection could be followed by regrowth of FD, but there is no method for indicating disease progress. Serum alkaline phosphatase (ALP) is significantly high in patients with FD. The authors investigate the relationship between ALP, progress of FD, and age at surgery. 18 patients with craniofacial FD were separated into 3 groups: Group A, complete resection; Group B, incomplete resection followed by regrowth of FD; and Group C, incomplete resection but no regrowth of FD. Medical records and CT scans were reviewed retrospectively. ALP levels were obtained preoperatively, postoperatively and every year during follow-up. The relation between ALP and regrowth and that between age at surgery and regrowth were investigated. There was no recurrence in Group A (n=4). Regrowth in Group B (n=7) was preceded by an abrupt increase in ALP. In Group C (n=7), no regrowth was observed and ALP was maintained within the normal range. 6 patients (85%) in Group B and 2 (28%) in Group C were under 17 years old. The results revealed that the level of postoperative serum ALP could be a reliable marker for predicting the progress of craniofacial FD.
Full Text
http://www.sciencedirect.com/science/article/pii/S0901502709011977
DOI
10.1016/j.ijom.2009.12.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Oock(김용욱) ORCID logo https://orcid.org/0000-0002-3756-4809
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100841
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