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Effect of Recombinant Human Epidermal Growth Factor Against Cutaneous Scar Formation in Murine Full-thickness Wound Healing

Authors
 Young Seok Kim  ;  Dae Hyun Lew  ;  Kwan Chul Tark  ;  Dong Kyun Rah  ;  Joon Pio Hong 
Citation
 Journal of Korean Medical Science, Vol.25(4) : 589-596, 2010 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2010
Abstract
A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the formation of cutaneous scars. Twenty Crl:CD-1 (ICR) mice were used and 2 full-thickness skin wounds were made on the dorsum of each mouse. One of the wounds was treated with recombinant human EGF by local application and the other was treated with saline for control until complete healing was achieved. The EGF-treated group's wounds healed faster than the control group's. The width of the scar was smaller by 30% and the area was smaller by 26% in the EGF-treated group. Inflammatory cell numbers were significantly lower in the EGF-treated group. The expression of transforming growth factor (TGF)-beta1 in the EGF-treated group was increased. It was observed that the amount of collagen in the EGF-treated group was larger than the control group. In the EGF-treated group, the visible external scars were less noticeable than that in the control group. These results suggest that EGF can reduce cutaneous scars by suppressing inflammatory reactions, decreasing expression of TGF-beta1, and mediating the formation of collagen
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DOI
10.3346/jkms.2010.25.4.589
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Seok(김영석) ORCID logo https://orcid.org/0000-0002-0981-2107
Rah, Dong Kyun(나동균)
Lew, Dae Hyun(유대현)
Tark, Kwan Chul(탁관철)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100832
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