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Double contrast-enhanced MRI of viral hepatitis-induced cirrhosis: correlation of gross morphological signs with hepatic fibrosis.

Authors
 J S YU  ;  J H SHIM  ;  J J CHUNG  ;  J H KIM  ;  K W KIM 
Citation
 BRITISH JOURNAL OF RADIOLOGY, Vol.83(987) : 212-217, 2010 
Journal Title
 BRITISH JOURNAL OF RADIOLOGY 
ISSN
 0007-1285 
Issue Date
2010
MeSH
Adult ; Aged ; Contrast Media ; Dextrans ; Feasibility Studies ; Female ; Ferrosoferric Oxide ; Gadolinium DTPA ; Gallbladder/pathology* ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/pathology ; Hepatitis C/complications ; Hepatitis C/pathology ; Humans ; Liver/pathology* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Magnetic Resonance Imaging/methods* ; Magnetite Nanoparticles ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult
Abstract
The purpose of this study was to evaluate the diagnostic ability of the expanded gallbladder fossa and right posterior hepatic notch signs for hepatic fibrosis determined by double contrast-enhanced MRI. For patients with chronic viral hepatitis B (n = 96) or hepatitis C (n = 13) who underwent gadopentate dimeglumine-enhanced dynamic MRI followed by ferucarbotran-enhanced gradient-echo imaging, the degree of parenchymal fibrosis was categorised into three groups based on the extent of reticulation and nodularity: (1) pre-cirrhotic or minimal fibrosis; (2) mild to moderate fibrosis; (3) advanced cirrhosis. Each group was evaluated for the presence of a sharp notch in the posterior-medial surface of the right lobe of the liver and expanded gallbladder fossa. The expanded gallbladder fossa sign gradually increased with an increasing degree of fibrosis (Group 1, 50%; Group 2, 61%; Group 3, 78%), and there was no significant difference (p>0.5) between hepatitis B (67%) and C (73%). In the case of the right posterior hepatic notch sign, only 6% of Group 1 and Group 2 patients were positive; 27% of hepatitis B patients and 90% of hepatitis C patients in Group 3 exhibited the sign (p<0.05). Owing to its low prevalence, even in advanced cirrhosis, the right posterior hepatic notch sign is of little value in the diagnosis of cirrhosis due to chronic hepatitis B virus infection, whereas an expanded gallbladder fossa could be used as a non-specific indicator of early fibrosis before the gross appearance of advanced hepatic fibrosis.
Files in This Item:
T201000746.pdf Download
DOI
10.1259/bjr/70974553
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100797
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