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Do patients with ulcerative colitis diagnosed at a young age have more severe disease activity than patients diagnosed when older?

Authors
 Lee J.H.  ;  Cheon J.H.  ;  Moon C.M.  ;  Park J.J.  ;  Hong S.P.  ;  Kim T.I.  ;  Kim W.H. 
Citation
 DIGESTION, Vol.81(4) : 237-243, 2010 
Journal Title
 DIGESTION 
ISSN
 0012-2823 
Issue Date
2010
MeSH
Adolescent ; Adrenal Cortex Hormones/administration & dosage ; Adult ; Age Distribution ; Age Factors ; Biopsy, Needle ; Cohort Studies ; Colitis, Ulcerative/diagnosis* ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/epidemiology* ; Disease Progression ; Early Diagnosis ; Female ; Humans ; Immunohistochemistry ; Immunosuppressive Agents/administration & dosage ; Incidence ; Intestinal Mucosa/pathology ; Korea/epidemiology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Keywords
Age ; Ulcerative colitis ; Prognosis, ulcerative colitis
Abstract
BACKGROUND/AIMS: To compare the clinical features and disease behavior of ulcerative colitis (UC) according to the age at onset. METHODS: This retrospective study included 455 patients with UC who were diagnosed and treated between 1990 and 2008 at a single tertiary institution in Korea. The patients were divided into 2 groups according to their age at diagnosis of UC: an elderly group (>or=40 years) and a young group (<40 years). Clinical findings at diagnosis, extent of disease, treatment modalities used, cumulative admission rates, cumulative relapse rates, and surgery rates were analyzed according to these age groups. RESULTS: Two hundred and forty-two patients with UC (53.2%) were diagnosed before the age of 40 years. Disease severity at initial presentation as assessed by diarrhea frequency, the presence of pancolitis, and the use of steroids were higher in the young group; however, clinical disease course including cumulative admission rates, cumulative relapse rates, and surgery rates were not significantly different between the 2 groups. CONCLUSIONS: Certain clinical features and the extent of disease in UC patients appear to be more severe when the disease is diagnosed at younger age; however, their disease course and prognosis might not be different from those of their older counterparts.
Full Text
http://www.karger.com/Article/FullText/253850
DOI
10.1159/000253850
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Moon, Chang Mo(문창모)
Park, Jae Jun(박재준)
Lee, Jin Ha(이진하)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100784
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