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Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent.

 Jin-Young Choi  ;  Jin-Sub Choi MD  ;  Myeong-Jin Kim  ;  Joon Seok Lim  ;  Mi Suk Park  ;  Joo Hee Kim  ;  Yong Eun Chung 
 Journal of Magnetic Resonance Imaging, Vol.31(3) : 571-578, 2010 
Journal Title
 Journal of Magnetic Resonance Imaging 
Issue Date
Aged ; Algorithms* ; Biliary Tract/pathology ; Contrast Media ; Female ; Humans ; Image Enhancement/methods* ; Liver/pathology ; Liver Neoplasms/complications ; Liver Neoplasms/pathology* ; Liver Neoplasms/secondary* ; Male ; Meglumine/analogs & derivatives* ; Middle Aged ; Neovascularization, Pathologic/complications ; Neovascularization, Pathologic/pathology* ; Organometallic Compounds* ; Reproducibility of Results ; Sensitivity and Specificity
metastasis ; magnetic resonance imaging ; contrast agent ; gadobenate dimeglumine
PURPOSE: To assess the diagnostic performance of gadobenate dimeglumine-enhanced 3D gradient echo (3D-GRE) magnetic resonance imaging (MRI) for the detection of hepatic hypovascular metastases. MATERIALS AND METHODS: We retrospectively analyzed the initial radiologic reports of MRI of 41 patients with suspected hepatic metastases. Seventy-nine metastatic lesions were confirmed by histopathology or intraoperative ultrasound (IOUS). The sensitivity and positive predictive values for the diagnosis of hepatic metastasis were determined among each MRI set (hepatobiliary phase, precontrast images, dynamic imaging). The diagnostic performance of dynamic image set and combined dynamic and hepatobiliary image set was also evaluated by two radiologists using alternative free response receiver operating characteristic (ROC) analysis. RESULTS: The overall detection rate and positive predictive value of MR were 96.2% (76/79) and 96.2% (76/79), respectively. Images obtained with hepatobiliary phase 3D-GRE showed a significantly better detection rate compared to those with precontrast sequences or dynamic imaging (P = 0.008 and 0.016, respectively). Regarding lesions 1 cm or smaller, the detection rate was 90.3% (28/31). Each reader showed a higher Az value of the combined hepatobiliary image set than those of the dynamic image set. CONCLUSION: 3D-GRE MRI using a hepatobiliary contrast agent is an accurate tool in the detection of hepatic hypovascular metastases and improves detection rate compared with precontrast and dynamic imaging
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Choi, Jin Sub(최진섭)
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
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