330 359

Cited 20 times in

Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis

Authors
 Jung Tak Park  ;  Tae Ik Chang  ;  Dong Ki Kim  ;  Jung Eun Lee  ;  Hoon Young Choi  ;  Hyun Wook Kim  ;  Jae Hyun Chang  ;  Sun Young Park  ;  Eunyoung Kim  ;  Tae-Hyun Yoo  ;  Dae-Suk Han  ;  Shin-Wook Kang 
Citation
 NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.25(2) : 599-604, 2010 
Journal Title
 NEPHROLOGY DIALYSIS TRANSPLANTATION 
ISSN
 0931-0509 
Issue Date
2010
MeSH
Female ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/mortality* ; Kidney Failure, Chronic/therapy* ; Male ; Metabolic Syndrome/complications* ; Middle Aged ; Peritoneal Dialysis, Continuous Ambulatory* ; Prognosis ; Prospective Studies
Keywords
inflammation ; metabolic syndrome X ; mortality ; peritoneal dialysis
Abstract
BACKGROUND: Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients. Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for >3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period. RESULTS: Metabolic syndrome was present in 50 patients (47.2%), and these showed higher baseline hsCRP levels (0.67; 95% CI: 0.50-0.94 versus 1.78 mg/dl; 95% CI: 1.21-2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90% versus 67%, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95% CI: 1.16-9.94; P = 0.02), baseline albumin (RR: 0.06; 95% CI: 0.01-0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95% CI: 1.07-1.22; P < 0.001). CONCLUSION: Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients
Files in This Item:
T201000351.pdf Download
DOI
10.1093/ndt/gfp498
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Sun Young(박선영)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Chang, Jae Hyun(장제현)
Chang, Tae Ik(장태익)
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100640
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links