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Potential conditions causing impairment of selective hepatobiliary enhancement of gadobenate dimeglumine-enhanced delayed magnetic resonance imaging

Authors
 Honsoul Kim  ;  Myeong-Jin Kim  ;  Mi-Suk Park  ;  Seung-Whan Cha  ;  Joon Seok Lim  ;  Hyung Sik Yoo  ;  Ki Whang Kim 
Citation
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, Vol.34(1) : 113-120, 2010 
Journal Title
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 
ISSN
 0363-8715 
Issue Date
2010
MeSH
Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Aspartate Aminotransferases/blood ; Biliary Tract/metabolism* ; Bilirubin/blood ; Blood Urea Nitrogen ; Contrast Media/pharmacokinetics* ; Creatinine/blood ; Female ; Humans ; Image Enhancement/methods* ; Kidney Diseases/metabolism ; Liver/metabolism* ; Liver Diseases/metabolism ; Magnetic Resonance Imaging/methods* ; Male ; Meglumine/analogs & derivatives* ; Meglumine/pharmacokinetics ; Middle Aged ; Observer Variation ; Organometallic Compounds/pharmacokinetics* ; Retrospective Studies ; Splenomegaly/metabolism
Keywords
magnetic resonance imaging ; gadobenate dimeglumine ; selective hepatic enhancement ; hepatobiliary enhancement
Abstract
OBJECTIVE: To identify conditions that might impair the delayed selective hepatobiliary enhancement of gadobenate dimeglumine. MATERIALS AND METHODS: Ninety-five gadobenate-enhanced magnetic resonance imaging studies were retrospectively and independently analyzed. The effects of selective hepatic enhancement and biliary excretion were each categorized into 3 grades according to the perceived difference of signal intensity between the liver parenchyma and portal vein, and signal intensity in the common bile duct of precontrast- and delayed-phase images.History of diffuse liver disease, liver cirrhosis, and renal disease; elevated levels of blood urea nitrogen (BUN)/creatinine (Cr), aspartate aminotransferase (AST)/alanine aminotransferase, bilirubin, and alkaline phosphatase (ALP); ascites; and splenomegaly were compared according to the grade of hepatic and biliary enhancement. RESULTS: Diffuse liver disease (P = 0.002); cirrhosis (P < 0.001); renal disease (P = 0.022); ascites (P = 0.001); splenomegaly (P < 0.001); and elevated levels of BUN (P = 0.001), Cr (P = 0.003), AST (P < 0.001), bilirubin (P < 0.001), and ALP (P < 0.001) were factors that impaired selective hepatic enhancement. Biliary excretion was affected by the presence of liver disease (P < 0.001), cirrhosis (P < 0.001), splenomegaly (P < 0.001), ascites (P = 0.002), and elevated levels of Cr (P = 0.013), AST (<0.001), alanine aminotransferase (P = 0.001), bilirubin (P < 0.001), and ALP (P < 0.001). CONCLUSION: Delayed selective hepatobiliary enhancement of gadobenate dimeglumine can be impaired by liver or renal disease and/or by elevated levels of bilirubin, ALP, BUN, and Cr
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004728-201001000-00021&LSLINK=80&D=ovft
DOI
10.1097/RCT.0b013e3181aacd6b
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Yoo, Hyung Sik(유형식)
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100634
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