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Modification of mesenchymal stem cells for cardiac regeneration.

Authors
 Heesang Song  ;  Byeong-Wook Song  ;  Min-Ji Cha  ;  In-Geol Choi  ;  Ki-Chul Hwang 
Citation
 EXPERT OPINION ON BIOLOGICAL THERAPY, Vol.10(3) : 309-319, 2010 
Journal Title
 EXPERT OPINION ON BIOLOGICAL THERAPY 
ISSN
 1471-2598 
Issue Date
2010
MeSH
Heart/physiopathology* ; Heart Diseases/therapy* ; Humans ; Mesenchymal Stromal Cells/cytology* ; Regeneration* ; Stem Cell Transplantation*
Abstract
IMPORTANCE OF THE FIELD: Mesenchymal stem cells (MSCs) have the greatest potential for use in cell-based therapy of human heart diseases, especially in myocardial infarcts. The therapeutic potential of MSCs in myocardial repair is based on the ability of MSCs to directly differentiate into cardiac tissue and on the paracrine actions of factors released from MSCs. However, the major obstacle in the clinical application of MSC-based therapy is the poor viability of the transplanted cells due to harsh microenvironments like ischemia, inflammation and/or anoikis in the infarcted myocardium. Recently, various approaches have been implemented in an effort to improve the survival of implanted MSCs through ex vivo manipulation of MSCs. AREAS COVERED IN THIS REVIEW: Major obstacles in MSC-based therapy are discussed, along with recent advances for enhancing therapeutic potential of engrafted MSCs from the past decade. WHAT THE READER WILL GAIN: This review focuses primarily on ex vivo manipulation of MSCs before transplantation, which includes pretreatment, preconditioning and genetic modification of MSCs, and future directions. TAKE HOME MESSAGE: Modification of MSCs before transplantation has developed into a promising option for enhancing the beneficial effects of MSC-based therapy for cardiac repair after myocardial infarction.
Full Text
http://informahealthcare.com/doi/abs/10.1517/14712590903455997
DOI
10.1517/14712590903455997
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Song, Byeong Wook(송병욱)
Cha, Min Ji(차민지)
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100573
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