Cited 96 times in
Modification of mesenchymal stem cells for cardiac regeneration.
DC Field | Value | Language |
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dc.contributor.author | 송병욱 | - |
dc.contributor.author | 차민지 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2015-04-23T16:26:01Z | - |
dc.date.available | 2015-04-23T16:26:01Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1471-2598 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100573 | - |
dc.description.abstract | IMPORTANCE OF THE FIELD: Mesenchymal stem cells (MSCs) have the greatest potential for use in cell-based therapy of human heart diseases, especially in myocardial infarcts. The therapeutic potential of MSCs in myocardial repair is based on the ability of MSCs to directly differentiate into cardiac tissue and on the paracrine actions of factors released from MSCs. However, the major obstacle in the clinical application of MSC-based therapy is the poor viability of the transplanted cells due to harsh microenvironments like ischemia, inflammation and/or anoikis in the infarcted myocardium. Recently, various approaches have been implemented in an effort to improve the survival of implanted MSCs through ex vivo manipulation of MSCs. AREAS COVERED IN THIS REVIEW: Major obstacles in MSC-based therapy are discussed, along with recent advances for enhancing therapeutic potential of engrafted MSCs from the past decade. WHAT THE READER WILL GAIN: This review focuses primarily on ex vivo manipulation of MSCs before transplantation, which includes pretreatment, preconditioning and genetic modification of MSCs, and future directions. TAKE HOME MESSAGE: Modification of MSCs before transplantation has developed into a promising option for enhancing the beneficial effects of MSC-based therapy for cardiac repair after myocardial infarction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 309~319 | - |
dc.relation.isPartOf | EXPERT OPINION ON BIOLOGICAL THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Heart/physiopathology* | - |
dc.subject.MESH | Heart Diseases/therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology* | - |
dc.subject.MESH | Regeneration* | - |
dc.subject.MESH | Stem Cell Transplantation* | - |
dc.title | Modification of mesenchymal stem cells for cardiac regeneration. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Heesang Song | - |
dc.contributor.googleauthor | Byeong-Wook Song | - |
dc.contributor.googleauthor | Min-Ji Cha | - |
dc.contributor.googleauthor | In-Geol Choi | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.1517/14712590903455997 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02026 | - |
dc.contributor.localId | A03995 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J00877 | - |
dc.identifier.eissn | 1744-7682 | - |
dc.identifier.pmid | 20132054 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1517/14712590903455997 | - |
dc.contributor.alternativeName | Song, Byeong Wook | - |
dc.contributor.alternativeName | Cha, Min Ji | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Song, Byeong Wook | - |
dc.contributor.affiliatedAuthor | Cha, Min Ji | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 309 | - |
dc.citation.endPage | 319 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON BIOLOGICAL THERAPY, Vol.10(3) : 309-319, 2010 | - |
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