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Clinicopathologic report of uveal melanoma with persistent exudative retinal detachment after gamma knife radiosurgery

 Song W.K.  ;  Yang W.I.  ;  Byeon S.H.  ;  Koh H.J.  ;  Kwon O.W.  ;  Lee S.C. 
 OPHTHALMOLOGICA, Vol.224(1) : 16-21, 2010 
Journal Title
Issue Date
Adult ; Exudates and Transudates* ; Eye Enucleation ; Humans ; Male ; Melanoma/pathology ; Melanoma/surgery* ; Middle Aged ; Necrosis ; Postoperative Complications/etiology* ; Postoperative Complications/pathology ; Postoperative Complications/surgery ; Radiosurgery/adverse effects* ; Retinal Detachment/etiology* ; Retinal Detachment/pathology ; Retinal Detachment/surgery ; Retrospective Studies ; Silicone Oils ; Uveal Neoplasms/pathology ; Uveal Neoplasms/surgery* ; Vitrectomy
Gamma Knife radiosurgery ; Uveal melanoma ; Retinal detachment ; Histopathology after radiation
AIMS: Our purpose was to report the clinical and pathological findings from uveal melanoma patients with persistent exudative retinal detachment (RD) after Gamma Knife radiosurgery (GKR).

METHODS: A retrospective review was performed.

RESULTS: GKR was performed on 19 uveal melanoma patients from 2004 to 2006, and 5 of them developed persistent exudative RD. The mean initial largest basal tumor diameter in these 5 patients was 14.4 +/- 1.9 mm, and the mean tumor height was 9.2 +/- 1.0 mm. Marginal doses of 40-50 Gy radiation were administered. RD developed or had become aggravated an average of 3 (1-10) months after GKR. Two patients underwent enucleation, while the remaining 3 underwent tumor removal by endoresection with retinal reattachment surgery by vitrectomy and silicone oil tamponade. These procedures were undertaken an average of 6.3 (1.5-14) months after radiation and 3.3 (0.5-5) months after the onset or aggravation of RD. Histologically 4 tumors showed 50-100% necrosis without any mitotic activity. Thus local tumor control after GKR appeared sufficient regardless of RD.

CONCLUSION: Aggravation or development of exudative RD after GKR does not necessarily entail treatment failure. Therefore, retinal reattachment surgery in persistent exudative RD may be an option to preserve the eye.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kwon, Oh Woong(권오웅)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Song, Won Kyung(송원경)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
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