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Diagnosis and staging of primary ovarian cancer: correlation between PET/CT, Doppler US, and CT or MRI

Authors
 Eun Ji Nam  ;  Mi Jin Yun  ;  Young Taik Oh  ;  Jae Wook Kim  ;  Jae Hoon Kim  ;  Sunghoon Kim  ;  Yong Wook Jung  ;  Sang Wun Kim  ;  Young Tae Kim 
Citation
 GYNECOLOGIC ONCOLOGY, Vol.116(3) : 389-394, 2010 
Journal Title
 GYNECOLOGIC ONCOLOGY 
ISSN
 0090-8258 
Issue Date
2010
MeSH
Adolescent ; Adult ; Aged ; Female ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms/diagnosis* ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/pathology ; Positron-Emission Tomography ; ROC Curve ; Radiopharmaceuticals ; Tomography, X-Ray Computed ; Ultrasonography, Doppler ; Young Adult
Keywords
Ovarian cancer ; PET/CT ; Diagnostic imaging
Abstract
PURPOSE: To compare the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT), pelvic Doppler ultrasonography (US), abdomino-pelvic computed tomography (CT), and pelvic magnetic resonance imaging (MRI) for detection of ovarian cancer and to assess the role of PET/CT in evaluating the dissemination of ovarian cancer. PATIENTS AND METHODS: One hundred thirty-three women suspected to have ovarian cancer were enrolled in a prospective study before surgery between March 2005 and August 2007. The accuracy of each modality in detection of malignancy was estimated by computing the relevant areas under a receiver operating characteristics curve. Histopathologic results served as the reference standard. RESULTS: Histopathology showed benign tumors in 25 patients, borderline tumors in 13 patients, and malignant tumors in 95 patients. In distinguishing malignant/borderline from benign ovarian tumors, the accuracy of PET/CT (0.921) was higher than that of pelvis US (0.830) and abdomino-pelvic CT or pelvis MRI (0.749; P=0.013). Radiologic staging by PET/CT was concordant with surgical staging in 78% of patient and PET/CT revealed 15 (15.8%) unpredicted extra-abdominal lymph node metastasis in 95 patients with ovarian cancer. In addition, PET/CT detected new, unexpected co-existing malignant tumors in five (3.8%) cases including two thyroid tumors, two breast tumors, and one pancreatic neuroendocrine cancer. CONCLUSION: PET/CT is superior to pelvis US, abdomino-pelvic CT, and pelvic MRI for diagnosis of malignant ovarian tumors and is useful in revealing metastatic ovarian cancer and co-existing malignant tumors. Therefore, we suggest that PET/CT could be used during pre-operative evaluation of patients suspected to have ovarian cancer.
Full Text
http://www.sciencedirect.com/science/article/pii/S0090825809008634
DOI
10.1016/j.ygyno.2009.10.059
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Nam, Eun Ji(남은지)
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Jung, Yong Wook(정용욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100487
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