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Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy

Authors
 Yun Jin Lee  ;  Hoon-Chul Kang  ;  Sun Joon Bae  ;  Heung Dong Kim  ;  Jeong Tae Kim  ;  Byung In Lee  ;  Kyoung Heo  ;  Jin Woo Jang  ;  Dong Seok Kim  ;  Tae Seung Kim  ;  Joon Soo Lee 
Citation
 CHILDS NERVOUS SYSTEM, Vol.26(2) : 177-183, 2010 
Journal Title
CHILDS NERVOUS SYSTEM
ISSN
 0256-7040 
Issue Date
2010
MeSH
Adolescent ; Adult ; Age Factors ; AnteriorTemporalLobectomy*/adverse effects ; AnteriorTemporalLobectomy*/methods ; Brain/pathology ; Brain/physiopathology ; Brain/surgery ; Child ; Epilepsy, Generalized/pathology ; Epilepsy, Generalized/physiopathology ; Epilepsy, Generalized/surgery ; Epilepsy,TemporalLobe/pathology ; Epilepsy,TemporalLobe/physiopathology ; Epilepsy,TemporalLobe/surgery* ; Epilepsy, Tonic-Clonic/pathology ; Epilepsy, Tonic-Clonic/physiopathology ; Epilepsy, Tonic-Clonic/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; Seizures/pathology ; Seizures/physiopathology ; Seizures/surgery ; Treatment Outcome ; Young Adult
Keywords
Temporal lobe epilepsy ; Temporal lobectomy ; Children ; Adults
Abstract
INTRODUCTION: The aim of the study was to assess the difference in clinical characteristics and postsurgical outcomes between children and adults who have undergone temporal lobectomy (TL).

MATERIALS AND METHODS: We retrospectively reviewed the medical records of 52 patients who had undergone TL between 2006 and 2008. Nineteen patients were classified as children (18 years old) according to the age when TL had been performed.

RESULTS: Twelve of 19 (63.2%) children and 24 of 33 (72.7%) adults became seizure free. Rapid secondary generalization such as generalized tonic or tonic-clonic seizures showed a tendency to be more prominent in children (four of 19, 21.1%) than in adults (three of 33, 9.1%). Patients in childhood had significantly more multifocal discharges on interictal electroencephalography (EEG) (42.1%) compared to adults (15.2%, p = 0.014). The mean extent of surgical excision was 5.0 cm in children and 4.1 cm in adults (p = 0.001). The incidence of hippocampal sclerosis, the most common pathologic finding in the two groups, was 57.9% (11 of 19) in children and 78.8% (26 of 33) in adults. Malformations of cortical development were significantly more frequent in children (nine of 19, 47.4%) than in adults (seven of 33, 21.2%). Dual pathology was found in 31.6% of children and in 12.1% of adults. The intelligence quotient and memory quotient values in children with temporal lobe resection remained nearly steady during follow-up period without significant decline.

CONCLUSION: Patients undergoing TL during childhood compared to during adulthood had distinctively different interictal EEG, resectional extents, and pathologic findings.
Full Text
http://link.springer.com/article/10.1007%2Fs00381-009-1015-3
DOI
10.1007/s00381-009-1015-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Dong Seok(김동석)
Kim, Tai Seung(김태승)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Byung In(이병인)
Lee, Yun Jin(이윤진)
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100456
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