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Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy

Authors
 Yun Jin Lee  ;  Hoon-Chul Kang  ;  Sun Joon Bae  ;  Heung Dong Kim  ;  Jeong Tae Kim  ;  Byung In Lee  ;  Kyoung Heo  ;  Jin Woo Jang  ;  Dong Seok Kim  ;  Tae Seung Kim  ;  Joon Soo Lee 
Citation
 CHILDS NERVOUS SYSTEM, Vol.26(2) : 177-183, 2010 
Journal Title
 CHILDS NERVOUS SYSTEM 
ISSN
 0256-7040 
Issue Date
2010
MeSH
Adolescent ; Adult ; Age Factors ; Anterior Temporal Lobectomy*/adverse effects ; Anterior Temporal Lobectomy*/methods ; Brain/pathology ; Brain/physiopathology ; Brain/surgery ; Child ; Epilepsy, Generalized/pathology ; Epilepsy, Generalized/physiopathology ; Epilepsy, Generalized/surgery ; Epilepsy, Temporal Lobe/pathology ; Epilepsy, Temporal Lobe/physiopathology ; Epilepsy, Temporal Lobe/surgery* ; Epilepsy, Tonic-Clonic/pathology ; Epilepsy, Tonic-Clonic/physiopathology ; Epilepsy, Tonic-Clonic/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; Seizures/pathology ; Seizures/physiopathology ; Seizures/surgery ; Treatment Outcome ; Young Adult
Keywords
Temporal lobe epilepsy ;  Temporal lobectomy  ; Children ;  Adults 
Abstract
INTRODUCTION: The aim of the study was to assess the difference in clinical characteristics and postsurgical outcomes between children and adults who have undergone temporal lobectomy (TL). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 52 patients who had undergone TL between 2006 and 2008. Nineteen patients were classified as children (<or=18 years old), and 33 patients were classified as adults (>18 years old) according to the age when TL had been performed. RESULTS: Twelve of 19 (63.2%) children and 24 of 33 (72.7%) adults became seizure free. Rapid secondary generalization such as generalized tonic or tonic-clonic seizures showed a tendency to be more prominent in children (four of 19, 21.1%) than in adults (three of 33, 9.1%). Patients in childhood had significantly more multifocal discharges on interictal electroencephalography (EEG) (42.1%) compared to adults (15.2%, p = 0.014). The mean extent of surgical excision was 5.0 cm in children and 4.1 cm in adults (p = 0.001). The incidence of hippocampal sclerosis, the most common pathologic finding in the two groups, was 57.9% (11 of 19) in children and 78.8% (26 of 33) in adults. Malformations of cortical development were significantly more frequent in children (nine of 19, 47.4%) than in adults (seven of 33, 21.2%). Dual pathology was found in 31.6% of children and in 12.1% of adults. The intelligence quotient and memory quotient values in children with temporal lobe resection remained nearly steady during follow-up period without significant decline. CONCLUSION: Patients undergoing TL during childhood compared to during adulthood had distinctively different interictal EEG, resectional extents, and pathologic findings.
Full Text
http://link.springer.com/article/10.1007%2Fs00381-009-1015-3
DOI
10.1007/s00381-009-1015-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Dong Seok(김동석)
Kim, Tai Seung(김태승)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Byung In(이병인)
Lee, Yun Jin(이윤진)
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100456
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