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Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

Authors
 Hyung-In Moon  ;  Tae-im Kim  ;  Hyun-Soo Cho  ;  Eung Kweon Kim 
Citation
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.20(3) : 991-993, 2010 
Journal Title
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 
ISSN
 0960-894X 
Issue Date
2010
MeSH
Collagenases/metabolism ; Crataegus* ; Gelatinases/antagonists & inhibitors* ; Gelatinases/metabolism ; Humans ; Matrix Metalloproteinase Inhibitors* ; Plant Extracts/chemistry* ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology* ; Plant Leaves
Keywords
Crataegus pinnatifida ; Oligomeric procyanidins ; Collagenase ; Gelatinase
Abstract
Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.
Full Text
http://www.sciencedirect.com/science/article/pii/S0960894X0901782X
DOI
10.1016/j.bmcl.2009.12.059
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100443
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