Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

1 449

Cited 12 times in

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.20(3) : 991-993, 2010

MeSH: Collagenases/metabolism ; Crataegus* ; Gelatinases/antagonists &inhibitors* ; Gelatinases/metabolism ; Humans ; Matrix MetalloproteinaseInhibitors* ; Plant Extracts/chemistry* ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology* ; Plant Leaves

Keywords: Crataegus pinnatifida ; Oligomeric procyanidins ; Collagenase ; Gelatinase

Abstract: Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.

Full Text: http://www.sciencedirect.com/science/article/pii/S0960894X0901782X

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

Yonsei Authors: Kim, Eung Kweon(김응권) https://orcid.org/0000-0002-1453-8042
Kim, Tae-Im(김태임) https://orcid.org/0000-0001-6414-3842

Show full item record Find it @ YMLIB

YUHSpace: Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida