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Serum Thyroglobulin Adds No Additional Value to Ultrasonographic Features in a Thyroid Malignancy

Authors
 Inyoung Youn  ;  Ji Min Sung  ;  Eun-Kyung Kim  ;  Jin Young Kwak 
Citation
 ULTRASOUND QUARTERLY, Vol.30(4) : 287-290, 2014 
Journal Title
ULTRASOUND QUARTERLY
ISSN
 0894-8771 
Issue Date
2014
MeSH
Adolescent ; Adult ; Aged ; Biomarkers/blood ; Female ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Thyroglobulin/blood* ; Thyroid Nodule/blood* ; Thyroid Nodule/diagnosis* ; Ultrasonography/methods* ; Young Adult
Abstract
We investigated the adjunctive role of preoperative serum thyroglobulin (Tg) in the diagnosis of thyroid nodules. A retrospective study was performed on 374 thyroid nodules (363 benign and 11 malignant) in 360 patients (296 women and 64 men; mean age, 50.1 years; range, 16-86 years) between December 2010 and July 2011. We evaluated clinicopathologic characteristics of patients and ultrasonographic (US) features of the lesions including presurgical Tg levels. Univariate and multivariate analysis were used to determine independent predictors of malignancy. Serum Tg was positively correlated with nodule size and thyroid volume (P < 0.001). There was no difference in serum Tg levels between malignant and benign nodules. Suspicious US features of thyroid nodules were the only independent predictors of malignancy (P< 0.001). Preoperative serum Tg was not useful in differentiating thyroid cancer from benign nodules. Suspicious US features were the only predicting factors for malignancy.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00013644-201412000-00008&LSLINK=80&D=ovft
DOI
10.1097/RUQ.0000000000000056
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100377
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