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Instability of 24-hour intraocular pressure fluctuation in healthy young subjects: a prospective, cross-sectional study

 Yoo Kyung Song  ;  Chang-Kyu Lee  ;  Jiwon Kim  ;  Samin Hong  ;  Chan Yun Kim  ;  Gong Je Seong 
 BMC OPHTHALMOLOGY, Vol.14(127) : 1-8, 2014 
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Adult ; Blood Pressure/physiology ; Circadian Rhythm/physiology* ; Cross-Sectional Studies ; Female ; Healthy Volunteers ; Humans ; Intraocular Pressure/physiology* ; Posture ; Prospective Studies ; Reproducibility of Results ; Tonometry, Ocular
Blood pressure ; Fluctuation ; Glaucoma ; Intraocular pressure
BACKGROUND: Elevated intraocular pressure (IOP) is a major risk factor for the development and/or progression of glaucoma, and a large diurnal IOP fluctuation has been identified as an independent risk factor of glaucoma progression. However, most previous studies have not considered the repeatability of 24-hour IOP measurements. The aim of this study was to evaluate the instability of 24-hour IOP fluctuations in healthy young subjects. METHODS: Ten healthy young volunteers participated in this prospective, cross-sectional study. Each subject underwent 24-hour IOP and systolic/diastolic blood pressure (SBP/DBP) assessments both in sitting and supine positions every 3 hours, once a week for 5 consecutive weeks. Mean ocular perfusion pressure (MOPP) was then calculated for both positions. The intraclass correlation coefficients (ICCs) of maximum, minimum, and fluctuation parameters were computed for IOP, SBP/DBP, and MOPP. Fluctuation was defined as the difference between maximum and minimum values during a day. RESULTS: Among the serial measurements taken over a 24-hour rhythm, the maximum/minimum values of IOP, as well as BP, showed excellent agreement: regardless of position, all ICC values were over 0.800. Most of the BP fluctuation values also showed excellent agreement. IOP fluctuation, however, did not show excellent agreement; the ICC of sitting IOP fluctuation was just 0.212. MOPP fluctuation also showed poor agreement, especially in the sitting position (ICC, 0.003). CONCLUSION: On a day to day basis, 24-hour IOP fluctuations were not highly reproducible in healthy young volunteers. Our results imply that a single 24-hour IOP assessment may not be a sufficient or suitable way to characterize circadian IOP fluctuations for individual subjects.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Song, Yoo Kyung(송유경)
Lee, Chang Kyu(이창규)
Hong, Sa Min(홍사민)
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