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Instability of 24-hour intraocular pressure fluctuation in healthy young subjects: a prospective, cross-sectional study

DC Field Value Language
dc.contributor.author김찬윤-
dc.contributor.author성공제-
dc.contributor.author송유경-
dc.contributor.author이창규-
dc.contributor.author홍사민-
dc.date.accessioned2015-01-06T17:36:53Z-
dc.date.available2015-01-06T17:36:53Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100308-
dc.description.abstractBACKGROUND: Elevated intraocular pressure (IOP) is a major risk factor for the development and/or progression of glaucoma, and a large diurnal IOP fluctuation has been identified as an independent risk factor of glaucoma progression. However, most previous studies have not considered the repeatability of 24-hour IOP measurements. The aim of this study was to evaluate the instability of 24-hour IOP fluctuations in healthy young subjects. METHODS: Ten healthy young volunteers participated in this prospective, cross-sectional study. Each subject underwent 24-hour IOP and systolic/diastolic blood pressure (SBP/DBP) assessments both in sitting and supine positions every 3 hours, once a week for 5 consecutive weeks. Mean ocular perfusion pressure (MOPP) was then calculated for both positions. The intraclass correlation coefficients (ICCs) of maximum, minimum, and fluctuation parameters were computed for IOP, SBP/DBP, and MOPP. Fluctuation was defined as the difference between maximum and minimum values during a day. RESULTS: Among the serial measurements taken over a 24-hour rhythm, the maximum/minimum values of IOP, as well as BP, showed excellent agreement: regardless of position, all ICC values were over 0.800. Most of the BP fluctuation values also showed excellent agreement. IOP fluctuation, however, did not show excellent agreement; the ICC of sitting IOP fluctuation was just 0.212. MOPP fluctuation also showed poor agreement, especially in the sitting position (ICC, 0.003). CONCLUSION: On a day to day basis, 24-hour IOP fluctuations were not highly reproducible in healthy young volunteers. Our results imply that a single 24-hour IOP assessment may not be a sufficient or suitable way to characterize circadian IOP fluctuations for individual subjects.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~8-
dc.relation.isPartOfBMC OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBlood Pressure/physiology-
dc.subject.MESHCircadian Rhythm/physiology*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHealthy Volunteers-
dc.subject.MESHHumans-
dc.subject.MESHIntraocular Pressure/physiology*-
dc.subject.MESHPosture-
dc.subject.MESHProspective Studies-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHTonometry, Ocular-
dc.titleInstability of 24-hour intraocular pressure fluctuation in healthy young subjects: a prospective, cross-sectional study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorYoo Kyung Song-
dc.contributor.googleauthorChang-Kyu Lee-
dc.contributor.googleauthorJiwon Kim-
dc.contributor.googleauthorSamin Hong-
dc.contributor.googleauthorChan Yun Kim-
dc.contributor.googleauthorGong Je Seong-
dc.identifier.doi10.1186/1471-2415-14-127-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01035-
dc.contributor.localIdA01946-
dc.contributor.localIdA02046-
dc.contributor.localIdA04395-
dc.contributor.localIdA03241-
dc.relation.journalcodeJ00370-
dc.identifier.eissn1471-2415-
dc.identifier.pmid25370361-
dc.subject.keywordBlood pressure-
dc.subject.keywordFluctuation-
dc.subject.keywordGlaucoma-
dc.subject.keywordIntraocular pressure-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.alternativeNameSeong, Gong Je-
dc.contributor.alternativeNameSong, Yoo Kyung-
dc.contributor.alternativeNameLee, Chang Kyu-
dc.contributor.alternativeNameHong, Sa Min-
dc.contributor.affiliatedAuthorKim, Chan Yun-
dc.contributor.affiliatedAuthorSeong, Gong Je-
dc.contributor.affiliatedAuthorSong, Yoo Kyung-
dc.contributor.affiliatedAuthorHong, Sa Min-
dc.contributor.affiliatedAuthorLee, Chang Kyu-
dc.citation.volume14-
dc.citation.number127-
dc.citation.startPage1-
dc.citation.endPage8-
dc.identifier.bibliographicCitationBMC OPHTHALMOLOGY, Vol.14(127) : 1-8, 2014-
dc.identifier.rimsid57580-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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