Cited 33 times in
Instability of 24-hour intraocular pressure fluctuation in healthy young subjects: a prospective, cross-sectional study
DC Field | Value | Language |
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dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 성공제 | - |
dc.contributor.author | 송유경 | - |
dc.contributor.author | 이창규 | - |
dc.contributor.author | 홍사민 | - |
dc.date.accessioned | 2015-01-06T17:36:53Z | - |
dc.date.available | 2015-01-06T17:36:53Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100308 | - |
dc.description.abstract | BACKGROUND: Elevated intraocular pressure (IOP) is a major risk factor for the development and/or progression of glaucoma, and a large diurnal IOP fluctuation has been identified as an independent risk factor of glaucoma progression. However, most previous studies have not considered the repeatability of 24-hour IOP measurements. The aim of this study was to evaluate the instability of 24-hour IOP fluctuations in healthy young subjects. METHODS: Ten healthy young volunteers participated in this prospective, cross-sectional study. Each subject underwent 24-hour IOP and systolic/diastolic blood pressure (SBP/DBP) assessments both in sitting and supine positions every 3 hours, once a week for 5 consecutive weeks. Mean ocular perfusion pressure (MOPP) was then calculated for both positions. The intraclass correlation coefficients (ICCs) of maximum, minimum, and fluctuation parameters were computed for IOP, SBP/DBP, and MOPP. Fluctuation was defined as the difference between maximum and minimum values during a day. RESULTS: Among the serial measurements taken over a 24-hour rhythm, the maximum/minimum values of IOP, as well as BP, showed excellent agreement: regardless of position, all ICC values were over 0.800. Most of the BP fluctuation values also showed excellent agreement. IOP fluctuation, however, did not show excellent agreement; the ICC of sitting IOP fluctuation was just 0.212. MOPP fluctuation also showed poor agreement, especially in the sitting position (ICC, 0.003). CONCLUSION: On a day to day basis, 24-hour IOP fluctuations were not highly reproducible in healthy young volunteers. Our results imply that a single 24-hour IOP assessment may not be a sufficient or suitable way to characterize circadian IOP fluctuations for individual subjects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~8 | - |
dc.relation.isPartOf | BMC OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Pressure/physiology | - |
dc.subject.MESH | Circadian Rhythm/physiology* | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Healthy Volunteers | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraocular Pressure/physiology* | - |
dc.subject.MESH | Posture | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Tonometry, Ocular | - |
dc.title | Instability of 24-hour intraocular pressure fluctuation in healthy young subjects: a prospective, cross-sectional study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Yoo Kyung Song | - |
dc.contributor.googleauthor | Chang-Kyu Lee | - |
dc.contributor.googleauthor | Jiwon Kim | - |
dc.contributor.googleauthor | Samin Hong | - |
dc.contributor.googleauthor | Chan Yun Kim | - |
dc.contributor.googleauthor | Gong Je Seong | - |
dc.identifier.doi | 10.1186/1471-2415-14-127 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01035 | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A02046 | - |
dc.contributor.localId | A04395 | - |
dc.contributor.localId | A03241 | - |
dc.relation.journalcode | J00370 | - |
dc.identifier.eissn | 1471-2415 | - |
dc.identifier.pmid | 25370361 | - |
dc.subject.keyword | Blood pressure | - |
dc.subject.keyword | Fluctuation | - |
dc.subject.keyword | Glaucoma | - |
dc.subject.keyword | Intraocular pressure | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.alternativeName | Seong, Gong Je | - |
dc.contributor.alternativeName | Song, Yoo Kyung | - |
dc.contributor.alternativeName | Lee, Chang Kyu | - |
dc.contributor.alternativeName | Hong, Sa Min | - |
dc.contributor.affiliatedAuthor | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Song, Yoo Kyung | - |
dc.contributor.affiliatedAuthor | Hong, Sa Min | - |
dc.contributor.affiliatedAuthor | Lee, Chang Kyu | - |
dc.citation.volume | 14 | - |
dc.citation.number | 127 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.identifier.bibliographicCitation | BMC OPHTHALMOLOGY, Vol.14(127) : 1-8, 2014 | - |
dc.identifier.rimsid | 57580 | - |
dc.type.rims | ART | - |
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