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Dynamic enhancement pattern of HCC smaller than 3 cm in diameter on gadoxetic acid-enhanced MRI: comparison with multiphasic MDCT

 Vivian Y. Park  ;  Jin-Young Choi  ;  Yong Eun Chung  ;  Honsoul Kim  ;  Mi-Suk Park  ;  Joon Seok Lim  ;  Ki Whang Kim  ;  Myeong-Jin Kim 
 Liver International, Vol.34(10) : 1593-1602, 2014 
Journal Title
 Liver International 
Issue Date
BACKGROUND & AIMS: The dynamic enhancement pattern of HCCs smaller than 3 cm in diameter on gadoxetic acid-enhanced magnetic resonance imaging (MRI) have not been extensively investigated. We aimed to evaluate the dynamic enhancement patterns of small HCCs (≤3 cm) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and compare enhancement patterns with multiphasic multidetector computed tomography (MDCT) based on tumour cellular differentiation and size. METHODS: We retrospectively included 55 patients with 67 surgically confirmed small HCCs (≤3 cm) who underwent multiphasic MDCT and gadoxetic acid-enhanced MRI. Dynamic enhancement patterns were analysed according to tumour cellular differentiation and size. Hepatobiliary phase images were also analysed to assess their additional value. RESULTS: The proportion of small HCCs demonstrating the typical enhancement pattern differed depending on tumour cellular differentiation on both MRI (P = 0.001) and MDCT (P = 0.001), but differed depending on tumour size only on CT (P = 0.008). Gadoxetic acid-enhanced MRI more sensitively depicted the typical enhancement pattern than CT for all tumours (P = 0.001), for moderately or poorly differentiated HCCs (P = 0.021) and for HCCs ≤2 cm (P = 0.001). 80% of tumours with atypical enhancement could be diagnosed as HCC based on tumour size and hepatobiliary phase images. CONCLUSIONS: On both gadoxetic acid-enhanced MRI and multiphasic CT, the dynamic enhancement patterns of small HCCs (≤3 cm) differed according to tumour cellular differentiation. Gadoxetic acid-enhanced MRI more frequently demonstrated the typical HCC enhancement pattern than CT in small HCCs.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김기황(Kim, Ki Whang)
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
김한솔(Kim, Hon Soul)
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
박영진(Park, Vivian Youngjean) ORCID logo https://orcid.org/0000-0002-5135-4058
임준석(Lim, Joon Seok) ORCID logo https://orcid.org/0000-0002-0334-5042
정용은(Chung, Yong Eun) ORCID logo https://orcid.org/0000-0003-0811-9578
최진영(Choi, Jin Young) ORCID logo https://orcid.org/0000-0002-9025-6274
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