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Dopaminergic Modulation of Resting-State Functional Connectivity in De Novo Patients With Parkinson’s Disease

Authors
 KyoungWon Baik  ;  Jungho Cha  ;  Jee Hyun Ham  ;  Gwang-Min Baek  ;  Mun Kyung Sunwoo  ;  Jin Yong Hong  ;  Na-Young Shin  ;  Jae Seung Kim  ;  Jong-Min Lee  ;  Seung-Koo Lee  ;  Young Ho Sohn  ;  Phil Hyu Lee 
Citation
 Human Brain Mapping, Vol.35(11) : 5431-5441, 2014 
Journal Title
 Human Brain Mapping 
ISSN
 1065-9471 
Issue Date
2014
MeSH
Brain/blood supply ; Brain/diagnostic imaging ; Brain/pathology* ; Brain Mapping ; Dopamine/metabolism* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/blood supply ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiology* ; Oxygen/blood ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/pathology ; Positron-Emission Tomography ; Rest* ; Statistics as Topic ; Tropanes
Keywords
de novo Parkinson's disease ; dopamine ; resting-state functional connectivity
Abstract
Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug naïve de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hbm.22561/abstract
DOI
10.1002/hbm.22561
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Shin, Na Young(신나영)
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100219
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