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A case of eosinophilic fasciitis presenting as pitting edema of the lower extremities

 Hee Seon Lee  ;  Soo Jin Chang  ;  Myung Suk Kang  ;  Choon Sik Yoon  ;  Kyung Won Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
 Allergy Asthma & Immunology Research, Vol.6(2) : 179-182, 2014 
Journal Title
 Allergy Asthma & Immunology Research 
Issue Date
Eosinophilic fasciitis is a rare disease characterized by diffuse fasciitis with peripheral eosinophilia and progressive induration and thickening of the skin and soft tissues. We report a 19-year-old female who presented with pitting edema in both lower extremities. She had a history of excessive physical activity before her symptoms developed. Physical examination revealed 2+ pitting edema in both lower legs. She complained of mild pain in both knee joints and feet, with no tenderness or heating sensations. Laboratory results were unremarkable except for severe eosinophilia. Parasite infection, venous thrombosis, and cardiac and renal problems were excluded. A magnetic resonance imaging study of both lower extremities revealed increased signal intensity in the subcutaneous lesions, consistent with superficial inflammation of the fascia. Mixed perivenular lymphoplasmacytic and eosinophilic infiltration in the subcutaneous lesion were observed on biopsy. The patient was treated with corticosteroids, resulting in remarkable improvement in both edema and eosinophilia.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
강명숙(Kang, Myung Suk)
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
윤춘식(Yoon, Choon Sik) ORCID logo https://orcid.org/0000-0003-2010-6710
이희선(Lee, Hee Seon)
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