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Improvements in Memory after Medial Septum Stimulation Are Associated with Changes in Hippocampal Cholinergic Activity and Neurogenesis

Authors
 Da Un Jeong  ;  Ji Eun Lee  ;  Sung Eun Lee  ;  Won Seok Chang  ;  Sung June Kim  ;  Jin Woo Chang 
Citation
 BIOMED RESEARCH INTERNATIONAL, Vol.2014 : 568587, 2014 
Journal Title
 BIOMED RESEARCH INTERNATIONAL 
ISSN
 2314-6133 
Issue Date
2014
MeSH
Animals ; Antibodies, Monoclonal/administration & dosage* ; Deep Brain Stimulation ; Dementia/drug therapy* ; Dementia/pathology ; Electrodes, Implanted ; Hippocampus/drug effects ; Humans ; Maze Learning/drug effects ; Memory/drug effects* ; Neurogenesis/drug effects* ; Neurons/drug effects ; Rats ; Ribosome Inactivating Proteins, Type 1/administration & dosage* ; Septal Nuclei/drug effects*
Abstract
Deep brain stimulation (DBS) has been found to have therapeutic effects in patients with dementia, but DBS mechanisms remain elusive. To provide evidence for the effectiveness of DBS as a treatment for dementia, we performed DBS in a rat model of dementia with intracerebroventricular administration of 192 IgG-saporins. We utilized four groups of rats, group 1, unlesioned control; group 2, cholinergic lesion; group 3, cholinergic lesion plus medial septum (MS) electrode implantation (sham stimulation); group 4, cholinergic lesions plus MS electrode implantation and stimulation. During the probe test in the water maze, performance of the lesion group decreased for measures of time spent and the number of swim crossings over the previous platform location. Interestingly, the stimulation group showed an equivalent performance to the normal group on all measures. And these are partially reversed by the electrode implantation. Acetylcholinesterase activity in the hippocampus was decreased in lesion and implantation groups, whereas activity in the stimulation group was not different from the normal group. Hippocampal neurogenesis was increased in the stimulation group. Our results revealed that DBS of MS restores spatial memory after damage to cholinergic neurons. This effect is associated with an increase in hippocampal cholinergic activity and neurogenesis.
Files in This Item:
T201403721.pdf Download
DOI
10.1155/2014/568587
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lee, Ji Eun(이지은)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Dawoon E.(정다운)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100171
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