Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
Authors
Hyemoon Chung ; Hyuck Moon Kwon ; Jong-Youn Kim ; Young Won Yoon ; Jihyuk Rhee ; Eui-Young Choi ; Pil-Ki Min ; Bum-Kee Hong ; Se-Joong Rim ; Ji Hyun Yoon ; Sung-Joo Lee ; Jong-Kwan Park ; Myung-Hyun Kim ; Minhee Jo ; Jeong-Hee Yang ; Byoung Kwon Lee
Citation
YONSEI MEDICAL JOURNAL, Vol.55(6) : 1507-1515, 2014
PURPOSE:
Plasma lipoprotein-associated phospholipase A₂ (Lp-PLA₂) binds to low-density lipoprotein. The levels of Lp-PLA₂ reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS.
MATERIALS AND METHODS:
We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group).
RESULTS:
Lp-PLA₂ and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA₂ levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA₂ to the ACS model significantly increased the global χ² value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA₂ was 0.624 (p=0.004). The addition of Lp-PLA₂ level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS.
CONCLUSION:
Lp-PLA₂ levels are related to plaque stability and might be a diagnostic biomarker for ACS.