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Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome

 Hyemoon Chung  ;  Hyuck Moon Kwon  ;  Jong-Youn Kim  ;  Young Won Yoon  ;  Jihyuk Rhee  ;  Eui-Young Choi  ;  Pil-Ki Min  ;  Bum-Kee Hong  ;  Se-Joong Rim  ;  Ji Hyun Yoon  ;  Sung-Joo Lee  ;  Jong-Kwan Park  ;  Myung-Hyun Kim  ;  Minhee Jo  ;  Jeong-Hee Yang  ;  Byoung Kwon Lee 
 Yonsei Medical Journal, Vol.55(6) : 1507-1515, 2014 
Journal Title
 Yonsei Medical Journal 
Issue Date
PURPOSE: Plasma lipoprotein-associated phospholipase A₂ (Lp-PLA₂) binds to low-density lipoprotein. The levels of Lp-PLA₂ reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS AND METHODS: We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group). RESULTS: Lp-PLA₂ and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA₂ levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA₂ to the ACS model significantly increased the global χ² value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA₂ was 0.624 (p=0.004). The addition of Lp-PLA₂ level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS. CONCLUSION: Lp-PLA₂ levels are related to plaque stability and might be a diagnostic biomarker for ACS.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
김명현(Kim, Myung Hyun)
김종윤(Kim, Jong Youn) ORCID logo https://orcid.org/0000-0001-7040-8771
민필기(Min, Pil Ki) ORCID logo https://orcid.org/0000-0001-7033-7651
윤영원(Yoon, Young Won) ORCID logo https://orcid.org/0000-0002-0907-0350
윤지현(Yoon, Ji Hyun)
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이지혁(Rhee, Ji Hyuk)
임세중(Rim, Se Joong) ORCID logo https://orcid.org/0000-0002-7631-5581
정혜문(Chung, Hye Moon)
조민희(Cho, Min Hee)
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
홍범기(Hong, Bum Kee) ORCID logo https://orcid.org/0000-0002-6456-0184
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