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Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome

Authors
 Hyemoon Chung  ;  Hyuck Moon Kwon  ;  Jong-Youn Kim  ;  Young Won Yoon  ;  Jihyuk Rhee  ;  Eui-Young Choi  ;  Pil-Ki Min  ;  Bum-Kee Hong  ;  Se-Joong Rim  ;  Ji Hyun Yoon  ;  Sung-Joo Lee  ;  Jong-Kwan Park  ;  Myung-Hyun Kim  ;  Minhee Jo  ;  Jeong-Hee Yang  ;  Byoung Kwon Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.55(6) : 1507-1515, 2014 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2014
MeSH
1-Alkyl-2-acetylglycerophosphocholine Esterase/blood* ; Acute Coronary Syndrome/blood* ; Acute Coronary Syndrome/physiopathology ; Aged ; Aged, 80 and over ; Angina Pectoris ; Biomarkers/blood ; C-Reactive Protein/metabolism* ; Coronary Angiography ; Female ; Humans ; Lipoproteins, LDL/blood* ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Plaque, Atherosclerotic/blood ; ROC Curve ; Risk Factors
Keywords
Lp-PLA₂ ; acute coronary syndrome ; biomarker ; coronary atherosclerotic plaque instability
Abstract
PURPOSE: Plasma lipoprotein-associated phospholipase A₂ (Lp-PLA₂) binds to low-density lipoprotein. The levels of Lp-PLA₂ reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS AND METHODS: We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group). RESULTS: Lp-PLA₂ and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA₂ levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA₂ to the ACS model significantly increased the global χ² value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA₂ was 0.624 (p=0.004). The addition of Lp-PLA₂ level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS. CONCLUSION: Lp-PLA₂ levels are related to plaque stability and might be a diagnostic biomarker for ACS.
Files in This Item:
T201403689.pdf Download
DOI
10.3349/ymj.2014.55.6.1507
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Myung Hyun(김명현)
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Min, Pil Ki(민필기) ORCID logo https://orcid.org/0000-0001-7033-7651
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Yoon, Ji Hyun(윤지현)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Rhee, Ji Hyuk(이지혁)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Hye Moon(정혜문)
Cho, Min Hee(조민희)
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100141
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