Cited 18 times in
Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
DC Field | Value | Language |
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dc.contributor.author | 민필기 | - |
dc.contributor.author | 윤영원 | - |
dc.contributor.author | 윤지현 | - |
dc.contributor.author | 이병권 | - |
dc.contributor.author | 이지혁 | - |
dc.contributor.author | 임세중 | - |
dc.contributor.author | 정혜문 | - |
dc.contributor.author | 조민희 | - |
dc.contributor.author | 최의영 | - |
dc.contributor.author | 홍범기 | - |
dc.contributor.author | 김명현 | - |
dc.contributor.author | 김종윤 | - |
dc.contributor.author | 권혁문 | - |
dc.date.accessioned | 2015-01-06T17:31:32Z | - |
dc.date.available | 2015-01-06T17:31:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100141 | - |
dc.description.abstract | PURPOSE: Plasma lipoprotein-associated phospholipase A₂ (Lp-PLA₂) binds to low-density lipoprotein. The levels of Lp-PLA₂ reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS AND METHODS: We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group). RESULTS: Lp-PLA₂ and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA₂ levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA₂ to the ACS model significantly increased the global χ² value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA₂ was 0.624 (p=0.004). The addition of Lp-PLA₂ level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS. CONCLUSION: Lp-PLA₂ levels are related to plaque stability and might be a diagnostic biomarker for ACS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1507~1515 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood* | - |
dc.subject.MESH | Acute Coronary Syndrome/blood* | - |
dc.subject.MESH | Acute Coronary Syndrome/physiopathology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Angina Pectoris | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Coronary Angiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipoproteins, LDL/blood* | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Plaque, Atherosclerotic/blood | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Hyemoon Chung | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.contributor.googleauthor | Jong-Youn Kim | - |
dc.contributor.googleauthor | Young Won Yoon | - |
dc.contributor.googleauthor | Jihyuk Rhee | - |
dc.contributor.googleauthor | Eui-Young Choi | - |
dc.contributor.googleauthor | Pil-Ki Min | - |
dc.contributor.googleauthor | Bum-Kee Hong | - |
dc.contributor.googleauthor | Se-Joong Rim | - |
dc.contributor.googleauthor | Ji Hyun Yoon | - |
dc.contributor.googleauthor | Sung-Joo Lee | - |
dc.contributor.googleauthor | Jong-Kwan Park | - |
dc.contributor.googleauthor | Myung-Hyun Kim | - |
dc.contributor.googleauthor | Minhee Jo | - |
dc.contributor.googleauthor | Jeong-Hee Yang | - |
dc.contributor.googleauthor | Byoung Kwon Lee | - |
dc.identifier.doi | 10.3349/ymj.2014.55.6.1507 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01412 | - |
dc.contributor.localId | A02580 | - |
dc.contributor.localId | A02609 | - |
dc.contributor.localId | A02793 | - |
dc.contributor.localId | A03213 | - |
dc.contributor.localId | A03372 | - |
dc.contributor.localId | A03779 | - |
dc.contributor.localId | A03820 | - |
dc.contributor.localId | A04165 | - |
dc.contributor.localId | A04394 | - |
dc.contributor.localId | A00926 | - |
dc.contributor.localId | A00260 | - |
dc.contributor.localId | A00427 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 25323886 | - |
dc.subject.keyword | Lp-PLA₂ | - |
dc.subject.keyword | acute coronary syndrome | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | coronary atherosclerotic plaque instability | - |
dc.contributor.alternativeName | Min, Pil Ki | - |
dc.contributor.alternativeName | Yoon, Young Won | - |
dc.contributor.alternativeName | Yoon, Ji Hyun | - |
dc.contributor.alternativeName | Lee, Byoung Kwon | - |
dc.contributor.alternativeName | Rhee, Ji Hyuk | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.alternativeName | Chung, Hye Moon | - |
dc.contributor.alternativeName | Cho, Min Hee | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.alternativeName | Hong, Bum Kee | - |
dc.contributor.alternativeName | Kim, Myung Hyun | - |
dc.contributor.alternativeName | Kim, Jong Youn | - |
dc.contributor.alternativeName | Kwon, Hyuck Moon | - |
dc.contributor.affiliatedAuthor | Min, Pil Ki | - |
dc.contributor.affiliatedAuthor | Yoon, Young Won | - |
dc.contributor.affiliatedAuthor | Yoon, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Byoung Kwon | - |
dc.contributor.affiliatedAuthor | Rhee, Ji Hyuk | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Chung, Hye Moon | - |
dc.contributor.affiliatedAuthor | Cho, Min Hee | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Hong, Bum Kee | - |
dc.contributor.affiliatedAuthor | Kim, Jong Youn | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuck Moon | - |
dc.contributor.affiliatedAuthor | Kim, Myung Hyun | - |
dc.citation.volume | 55 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1507 | - |
dc.citation.endPage | 1515 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(6) : 1507-1515, 2014 | - |
dc.identifier.rimsid | 51703 | - |
dc.type.rims | ART | - |
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