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Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome

DC FieldValueLanguage
dc.contributor.author민필기-
dc.contributor.author윤영원-
dc.contributor.author윤지현-
dc.contributor.author이병권-
dc.contributor.author이지혁-
dc.contributor.author임세중-
dc.contributor.author정혜문-
dc.contributor.author조민희-
dc.contributor.author최의영-
dc.contributor.author홍범기-
dc.contributor.author김명현-
dc.contributor.author김종윤-
dc.contributor.author권혁문-
dc.date.accessioned2015-01-06T17:31:32Z-
dc.date.available2015-01-06T17:31:32Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100141-
dc.description.abstractPURPOSE: Plasma lipoprotein-associated phospholipase A₂ (Lp-PLA₂) binds to low-density lipoprotein. The levels of Lp-PLA₂ reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS AND METHODS: We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group). RESULTS: Lp-PLA₂ and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA₂ levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA₂ to the ACS model significantly increased the global χ² value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA₂ was 0.624 (p=0.004). The addition of Lp-PLA₂ level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS. CONCLUSION: Lp-PLA₂ levels are related to plaque stability and might be a diagnostic biomarker for ACS.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1507~1515-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH1-Alkyl-2-acetylglycerophosphocholine Esterase/blood*-
dc.subject.MESHAcute Coronary Syndrome/blood*-
dc.subject.MESHAcute Coronary Syndrome/physiopathology-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAngina Pectoris-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHC-Reactive Protein/metabolism*-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLipoproteins, LDL/blood*-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPlaque, Atherosclerotic/blood-
dc.subject.MESHROC Curve-
dc.subject.MESHRisk Factors-
dc.titleLipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorHyemoon Chung-
dc.contributor.googleauthorHyuck Moon Kwon-
dc.contributor.googleauthorJong-Youn Kim-
dc.contributor.googleauthorYoung Won Yoon-
dc.contributor.googleauthorJihyuk Rhee-
dc.contributor.googleauthorEui-Young Choi-
dc.contributor.googleauthorPil-Ki Min-
dc.contributor.googleauthorBum-Kee Hong-
dc.contributor.googleauthorSe-Joong Rim-
dc.contributor.googleauthorJi Hyun Yoon-
dc.contributor.googleauthorSung-Joo Lee-
dc.contributor.googleauthorJong-Kwan Park-
dc.contributor.googleauthorMyung-Hyun Kim-
dc.contributor.googleauthorMinhee Jo-
dc.contributor.googleauthorJeong-Hee Yang-
dc.contributor.googleauthorByoung Kwon Lee-
dc.identifier.doi10.3349/ymj.2014.55.6.1507-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01412-
dc.contributor.localIdA02580-
dc.contributor.localIdA02609-
dc.contributor.localIdA02793-
dc.contributor.localIdA03213-
dc.contributor.localIdA03372-
dc.contributor.localIdA03779-
dc.contributor.localIdA03820-
dc.contributor.localIdA04165-
dc.contributor.localIdA04394-
dc.contributor.localIdA00926-
dc.contributor.localIdA00260-
dc.contributor.localIdA00427-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid25323886-
dc.subject.keywordLp-PLA₂-
dc.subject.keywordacute coronary syndrome-
dc.subject.keywordbiomarker-
dc.subject.keywordcoronary atherosclerotic plaque instability-
dc.contributor.alternativeNameMin, Pil Ki-
dc.contributor.alternativeNameYoon, Young Won-
dc.contributor.alternativeNameYoon, Ji Hyun-
dc.contributor.alternativeNameLee, Byoung Kwon-
dc.contributor.alternativeNameRhee, Ji Hyuk-
dc.contributor.alternativeNameRim, Se Joong-
dc.contributor.alternativeNameChung, Hye Moon-
dc.contributor.alternativeNameCho, Min Hee-
dc.contributor.alternativeNameChoi, Eui Young-
dc.contributor.alternativeNameHong, Bum Kee-
dc.contributor.alternativeNameKim, Myung Hyun-
dc.contributor.alternativeNameKim, Jong Youn-
dc.contributor.alternativeNameKwon, Hyuck Moon-
dc.contributor.affiliatedAuthorMin, Pil Ki-
dc.contributor.affiliatedAuthorYoon, Young Won-
dc.contributor.affiliatedAuthorYoon, Ji Hyun-
dc.contributor.affiliatedAuthorLee, Byoung Kwon-
dc.contributor.affiliatedAuthorRhee, Ji Hyuk-
dc.contributor.affiliatedAuthorRim, Se Joong-
dc.contributor.affiliatedAuthorChung, Hye Moon-
dc.contributor.affiliatedAuthorCho, Min Hee-
dc.contributor.affiliatedAuthorChoi, Eui Young-
dc.contributor.affiliatedAuthorHong, Bum Kee-
dc.contributor.affiliatedAuthorKim, Jong Youn-
dc.contributor.affiliatedAuthorKwon, Hyuck Moon-
dc.contributor.affiliatedAuthorKim, Myung Hyun-
dc.citation.volume55-
dc.citation.number6-
dc.citation.startPage1507-
dc.citation.endPage1515-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(6) : 1507-1515, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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