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Imaging-Cytology Correlation of Thyroid Nodules with Initially Benign Cytology

Authors
 Shin Hye Hwang  ;  Ji Min Sung  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jin Young Kwak 
Citation
 INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, Vol.2014 : 491508, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 
ISSN
 1687-8337 
Issue Date
2014
Abstract
Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ultrasound (US) or FNA following a radiologist's opinion on concordance between imaging and cytologic results. We compared the risk of malignancy of nodules classified into subgroups according to the initial US features and imaging-cytology correlation. Results. Among included nodules, 11 nodules were proven to be malignant (1.6%) in follow-up FNA or surgery. The malignancy rate was higher in nodules with suspicious US features (11.4%) than in nodules without suspicious US features (0.5%, P < 0.001). When a thyroid nodule had discordant US findings on image review after having benign FNA results, malignancy rate increased to 23.3%, significantly higher than that of nodules with suspicious US features (P < 0.001). However, no significant difference was found in the risk of malignancy between the nodules without suspicious US features (0.5%) and imaging-cytology concordant nodules (0.6%, P = 0.438). Conclusions. Repeat FNA can be effectively limited to patients with cytologically benign thyroid nodules showing discordance in imaging-cytology correlation after initial biopsy, which reduces unnecessary repeat aspirations.
Files in This Item:
T201403541.pdf Download
DOI
10.1155/2014/491508
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100003
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