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Alveolar Bone Resorption Induced by CD4+CD45RB High-Density T-Cell Transfer in Immunocompromised Mice

DC Field Value Language
dc.contributor.author김창성-
dc.contributor.author박정철-
dc.contributor.author정임희-
dc.contributor.author최은영-
dc.date.accessioned2015-01-06T17:26:28Z-
dc.date.available2015-01-06T17:26:28Z-
dc.date.issued2014-
dc.identifier.issn0022-3492-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99984-
dc.description.abstractBACKGROUND: The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell-transferred animals, and to investigate the systemic osteogenic potential by transplanting human periodontal ligament stem cells (hPDLSCs) into these animals. METHODS: CD4(+)CD45RB(High) and CD4(+)CD45RB(Low) (antigen-experienced [memory, CD45RB low-density]) T cells were sorted and transferred into severe combined immunodeficiency (SCID) mice to induce inflammatory bowel disease-like syndrome (n = 8). hPDLSCs were transplanted into T-cell-transferred SCID mice to examine ectopic cementum formation 8 weeks after T-cell transfer. The mandibles and tibias of these mice were retrieved for microcomputed tomography (micro-CT), histomorphometric analysis, and isolation of ABCs 16 weeks after T-cell transfer. The in vitro osteogenic and adipogenic potentials of the ABCs were evaluated. RESULTS: Histologic and micro-CT analysis revealed that the transfer of CD4(+)CD45RB(High) T-cell subset was sufficient for alveolar bone resorption and affected the osteogenic/adipogenic potential of ABCs. Furthermore, it was found that CD4(+)CD45RB(High) T-cell-transferred animals have decreased systemic osteogenic potential, as evidenced using the in vivo ectopic hPDLSC transplantation model. CONCLUSION: CD4(+)CD45RB(High) T-cell transfer induced both alveolar bone resorption and reduced systemic osteogenic potential, with a concomitant downregulation of the osteogenic potential of ABCs.-
dc.description.statementOfResponsibilityopen-
dc.format.extente339~e347-
dc.relation.isPartOfJOURNAL OF PERIODONTOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdipogenesis/immunology-
dc.subject.MESHAdoptive Transfer/methods*-
dc.subject.MESHAdult-
dc.subject.MESHAlveolar Bone Loss/immunology*-
dc.subject.MESHAlveolar Bone Loss/pathology-
dc.subject.MESHAlveolar Process/pathology-
dc.subject.MESHAnimals-
dc.subject.MESHBone Density/immunology-
dc.subject.MESHCD4-Positive T-Lymphocytes/immunology*-
dc.subject.MESHCD4-Positive T-Lymphocytes/transplantation-
dc.subject.MESHCell Culture Techniques-
dc.subject.MESHCell Differentiation/immunology-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCementogenesis/immunology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunocompromised Host*-
dc.subject.MESHInflammatory Bowel Diseases/immunology-
dc.subject.MESHLeukocyte Common Antigens/immunology*-
dc.subject.MESHMale-
dc.subject.MESHMandible/immunology-
dc.subject.MESHMandible/pathology-
dc.subject.MESHMesenchymal Stromal Cells/immunology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHMice, SCID-
dc.subject.MESHOsteogenesis/immunology-
dc.subject.MESHPeriodontal Ligament/cytology-
dc.subject.MESHPeriodontal Ligament/immunology-
dc.subject.MESHStem Cell Transplantation/methods-
dc.subject.MESHTibia/immunology-
dc.subject.MESHTibia/pathology-
dc.subject.MESHX-Ray Microtomography/methods-
dc.subject.MESHYoung Adult-
dc.titleAlveolar Bone Resorption Induced by CD4+CD45RB High-Density T-Cell Transfer in Immunocompromised Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontology (치주과학)-
dc.contributor.googleauthorJung-Chul Park-
dc.contributor.googleauthorBo-Kyoung Kim-
dc.contributor.googleauthorIm-Hee Jung-
dc.contributor.googleauthorEunyoung Choi-
dc.contributor.googleauthorChang-Sung Kim-
dc.identifier.doi10.1902/jop.2014.140077-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01041-
dc.contributor.localIdA01653-
dc.contributor.localIdA04155-
dc.contributor.localIdA03703-
dc.relation.journalcodeJ01697-
dc.identifier.eissn1943-3670-
dc.identifier.pmid24678850-
dc.identifier.urlhttp://www.joponline.org/doi/abs/10.1902/jop.2014.140077-
dc.subject.keywordAlveolar bone loss-
dc.subject.keywordCD4-positive T-lymphocytes-
dc.subject.keywordinflammatory bowel diseases-
dc.contributor.alternativeNameKim, Chang Sung-
dc.contributor.alternativeNamePark, Jung Chul-
dc.contributor.alternativeNameJung, Im Hee-
dc.contributor.alternativeNameChoi, Eun Young-
dc.contributor.affiliatedAuthorKim, Chang Sung-
dc.contributor.affiliatedAuthorPark, Jung Chul-
dc.contributor.affiliatedAuthorChoi, Eun Young-
dc.contributor.affiliatedAuthorJung, Im Hee-
dc.rights.accessRightsfree-
dc.citation.volume85-
dc.citation.number9-
dc.citation.startPage339-
dc.citation.endPage347-
dc.identifier.bibliographicCitationJOURNAL OF PERIODONTOLOGY, Vol.85(9) : 339-347, 2014-
dc.identifier.rimsid54388-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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