Cited 3 times in
Alveolar Bone Resorption Induced by CD4+CD45RB High-Density T-Cell Transfer in Immunocompromised Mice
DC Field | Value | Language |
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dc.contributor.author | 김창성 | - |
dc.contributor.author | 박정철 | - |
dc.contributor.author | 정임희 | - |
dc.contributor.author | 최은영 | - |
dc.date.accessioned | 2015-01-06T17:26:28Z | - |
dc.date.available | 2015-01-06T17:26:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99984 | - |
dc.description.abstract | BACKGROUND: The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell-transferred animals, and to investigate the systemic osteogenic potential by transplanting human periodontal ligament stem cells (hPDLSCs) into these animals. METHODS: CD4(+)CD45RB(High) and CD4(+)CD45RB(Low) (antigen-experienced [memory, CD45RB low-density]) T cells were sorted and transferred into severe combined immunodeficiency (SCID) mice to induce inflammatory bowel disease-like syndrome (n = 8). hPDLSCs were transplanted into T-cell-transferred SCID mice to examine ectopic cementum formation 8 weeks after T-cell transfer. The mandibles and tibias of these mice were retrieved for microcomputed tomography (micro-CT), histomorphometric analysis, and isolation of ABCs 16 weeks after T-cell transfer. The in vitro osteogenic and adipogenic potentials of the ABCs were evaluated. RESULTS: Histologic and micro-CT analysis revealed that the transfer of CD4(+)CD45RB(High) T-cell subset was sufficient for alveolar bone resorption and affected the osteogenic/adipogenic potential of ABCs. Furthermore, it was found that CD4(+)CD45RB(High) T-cell-transferred animals have decreased systemic osteogenic potential, as evidenced using the in vivo ectopic hPDLSC transplantation model. CONCLUSION: CD4(+)CD45RB(High) T-cell transfer induced both alveolar bone resorption and reduced systemic osteogenic potential, with a concomitant downregulation of the osteogenic potential of ABCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e339~e347 | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipogenesis/immunology | - |
dc.subject.MESH | Adoptive Transfer/methods* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alveolar Bone Loss/immunology* | - |
dc.subject.MESH | Alveolar Bone Loss/pathology | - |
dc.subject.MESH | Alveolar Process/pathology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Density/immunology | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/transplantation | - |
dc.subject.MESH | Cell Culture Techniques | - |
dc.subject.MESH | Cell Differentiation/immunology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cementogenesis/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunocompromised Host* | - |
dc.subject.MESH | Inflammatory Bowel Diseases/immunology | - |
dc.subject.MESH | Leukocyte Common Antigens/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mandible/immunology | - |
dc.subject.MESH | Mandible/pathology | - |
dc.subject.MESH | Mesenchymal Stromal Cells/immunology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Mice, SCID | - |
dc.subject.MESH | Osteogenesis/immunology | - |
dc.subject.MESH | Periodontal Ligament/cytology | - |
dc.subject.MESH | Periodontal Ligament/immunology | - |
dc.subject.MESH | Stem Cell Transplantation/methods | - |
dc.subject.MESH | Tibia/immunology | - |
dc.subject.MESH | Tibia/pathology | - |
dc.subject.MESH | X-Ray Microtomography/methods | - |
dc.subject.MESH | Young Adult | - |
dc.title | Alveolar Bone Resorption Induced by CD4+CD45RB High-Density T-Cell Transfer in Immunocompromised Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jung-Chul Park | - |
dc.contributor.googleauthor | Bo-Kyoung Kim | - |
dc.contributor.googleauthor | Im-Hee Jung | - |
dc.contributor.googleauthor | Eunyoung Choi | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.identifier.doi | 10.1902/jop.2014.140077 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A01653 | - |
dc.contributor.localId | A04155 | - |
dc.contributor.localId | A03703 | - |
dc.relation.journalcode | J01697 | - |
dc.identifier.eissn | 1943-3670 | - |
dc.identifier.pmid | 24678850 | - |
dc.identifier.url | http://www.joponline.org/doi/abs/10.1902/jop.2014.140077 | - |
dc.subject.keyword | Alveolar bone loss | - |
dc.subject.keyword | CD4-positive T-lymphocytes | - |
dc.subject.keyword | inflammatory bowel diseases | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Park, Jung Chul | - |
dc.contributor.alternativeName | Jung, Im Hee | - |
dc.contributor.alternativeName | Choi, Eun Young | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Park, Jung Chul | - |
dc.contributor.affiliatedAuthor | Choi, Eun Young | - |
dc.contributor.affiliatedAuthor | Jung, Im Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 85 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 339 | - |
dc.citation.endPage | 347 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTOLOGY, Vol.85(9) : 339-347, 2014 | - |
dc.identifier.rimsid | 54388 | - |
dc.type.rims | ART | - |
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