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Association of pancreatic adenocarcinoma up-regulated factor expression in ovarian mucinous adenocarcinoma with poor prognosis

Authors
 Sang Kyum Kim  ;  Si Young Song  ;  Sunghoon Kim  ;  Nam Hoon Cho  ;  Ga Won Yim  ;  Sang Wun Kim  ;  Young Tae Kim  ;  Eun Ji Nam 
Citation
 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.7(8) : 5103-5110, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 
Issue Date
2014
MeSH
Adult ; Biomarkers, Tumor/analysis* ; Cystadenocarcinoma, Mucinous/metabolism ; Cystadenocarcinoma, Mucinous/mortality ; Cystadenocarcinoma, Mucinous/pathology* ; Cystadenoma, Mucinous/metabolism ; Cystadenoma, Mucinous/mortality ; Cystadenoma, Mucinous/pathology ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lectins/analysis ; Lectins/biosynthesis* ; Middle Aged ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology* ; Prognosis ; Proportional Hazards Models
Keywords
Mucinous tumor ; PAUF ; ovary ; prognostic factor
Abstract
Pancreatic adenocarcinoma up-regulated factor (PAUF) expression is elevated in both ovarian tumors and pancreatic adenocarcinoma. However, PAUF expression in ovarian tumors according to histologic subtype and grade has not been investigated. In this study, we examined various clinicopathologic features of 24 patients with mucinous cystadenoma (MCA), 36 with mucinous borderline tumors (MBTs), and 46 with mucinous adenocarcinomas (MACs) according to PAUF expression status assessed using immunohistochemistry. We found that MACs more frequently stained positive for PAUF than did MCAs and MBTs (P < 0.0001). Although there was no significant differences with respect to other clinicopathologic characteristics of MACs according to PAUF expression status, patients with PAUF-weakly positive and PAUF-strongly positive MACs tended to have a shorter overall survival (OS) than those with PAUF-negative MAC, determined using a Kaplan–Meier analysis (P = 0.1885). After adjusting for various clinicopathologic parameters, PAUF positivity of MACs was a significant predictive factor for disease-free survival (DFS) (negative vs. weakly positive: P = 0.045, hazard ratio [HR] = 57.406, 95% confidence interval [CI]: 1.090-3022.596; and negative vs. strongly positive: P = 0.034, HR = 97.890, 95% CI: 1.412-6785.925). In conclusion, PAUF was more frequently expressed in MAC than in its benign and borderline counterparts, and was associated with a poor OS and DFS in MAC patients. Therefore, we suggest that PAUF may be a practical biomarker for histopathological categorization and a prognostic marker for patients with an ovarian mucinous tumor.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Kyum(김상겸) ORCID logo https://orcid.org/0000-0003-0768-9923
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Yim, Ga Won(임가원)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99952
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