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Association of pancreatic adenocarcinoma up-regulated factor expression in ovarian mucinous adenocarcinoma with poor prognosis
DC Field | Value | Language |
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dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 임가원 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 김상겸 | - |
dc.date.accessioned | 2015-01-06T17:25:26Z | - |
dc.date.available | 2015-01-06T17:25:26Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99952 | - |
dc.description.abstract | Pancreatic adenocarcinoma up-regulated factor (PAUF) expression is elevated in both ovarian tumors and pancreatic adenocarcinoma. However, PAUF expression in ovarian tumors according to histologic subtype and grade has not been investigated. In this study, we examined various clinicopathologic features of 24 patients with mucinous cystadenoma (MCA), 36 with mucinous borderline tumors (MBTs), and 46 with mucinous adenocarcinomas (MACs) according to PAUF expression status assessed using immunohistochemistry. We found that MACs more frequently stained positive for PAUF than did MCAs and MBTs (P < 0.0001). Although there was no significant differences with respect to other clinicopathologic characteristics of MACs according to PAUF expression status, patients with PAUF-weakly positive and PAUF-strongly positive MACs tended to have a shorter overall survival (OS) than those with PAUF-negative MAC, determined using a Kaplan–Meier analysis (P = 0.1885). After adjusting for various clinicopathologic parameters, PAUF positivity of MACs was a significant predictive factor for disease-free survival (DFS) (negative vs. weakly positive: P = 0.045, hazard ratio [HR] = 57.406, 95% confidence interval [CI]: 1.090-3022.596; and negative vs. strongly positive: P = 0.034, HR = 97.890, 95% CI: 1.412-6785.925). In conclusion, PAUF was more frequently expressed in MAC than in its benign and borderline counterparts, and was associated with a poor OS and DFS in MAC patients. Therefore, we suggest that PAUF may be a practical biomarker for histopathological categorization and a prognostic marker for patients with an ovarian mucinous tumor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 5103~5110 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Cystadenocarcinoma, Mucinous/metabolism | - |
dc.subject.MESH | Cystadenocarcinoma, Mucinous/mortality | - |
dc.subject.MESH | Cystadenocarcinoma, Mucinous/pathology* | - |
dc.subject.MESH | Cystadenoma, Mucinous/metabolism | - |
dc.subject.MESH | Cystadenoma, Mucinous/mortality | - |
dc.subject.MESH | Cystadenoma, Mucinous/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lectins/analysis | - |
dc.subject.MESH | Lectins/biosynthesis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism | - |
dc.subject.MESH | Ovarian Neoplasms/mortality | - |
dc.subject.MESH | Ovarian Neoplasms/pathology* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.title | Association of pancreatic adenocarcinoma up-regulated factor expression in ovarian mucinous adenocarcinoma with poor prognosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Ga Won Yim | - |
dc.contributor.googleauthor | Sang Wun Kim | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.contributor.googleauthor | Eun Ji Nam | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03354 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A00520 | - |
dc.contributor.localId | A00595 | - |
dc.relation.journalcode | J01096 | - |
dc.identifier.eissn | 1936-2625 | - |
dc.identifier.pmid | 25197383 | - |
dc.subject.keyword | Mucinous tumor | - |
dc.subject.keyword | PAUF | - |
dc.subject.keyword | ovary | - |
dc.subject.keyword | prognostic factor | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Yim, Ga Won | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Yim, Ga Won | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.citation.volume | 7 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5103 | - |
dc.citation.endPage | 5110 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.7(8) : 5103-5110, 2014 | - |
dc.identifier.rimsid | 53908 | - |
dc.type.rims | ART | - |
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