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Effects of GC7101, a Novel Prokinetic Agent on Gastric Motor Function: Ex Vivo Study

Authors
 Da Hyun Jung  ;  Eun Ju Choi  ;  Han Ho Jeon  ;  Young Ho Lee  ;  Hyojin Park 
Citation
 JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.20(4) : 469-474, 2014 
Journal Title
 JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 
ISSN
 2093-0879 
Issue Date
2014
Keywords
Functional dyspepsia ; Gastrointestinal motility ; Lonicera Flos ; Prokinetic
Abstract
BACKGROUND/AIMS: GC7101, an extract of Lonicera Flos, is a novel developing drug for reflux esophagitis and functional dyspepsia. However, the drug's exact pharmacological mechanism of action remains unclear. This study assessed the effects of GC7101 on gastro-intestinal (GI) motor function. METHODS: We used male guinea pigs to evaluate the effects of GC7101 on GI motility. The contraction of antral circular muscle in the presence of different doses of GC7101 was measured in a tissue bath. The prokinetic effects of GC7101 were tested using the charcoal transit assay from the pylorus to the most distal point of migration of charcoal mixture. To clarify the mechanism of action of GC7101, atropine, dopamine and the selective 5-hydroxytryptamine 4 receptor antagonist, GR113808 were used. RESULTS: The maximal amplitude of circular muscle contraction was induced by 5 mg mL(-1) GC7101. The area under the curve of con-traction was significantly increased at 5 mg mL(-1) GC7101. Addition of 10(-6) M atropine, 10(-8) M dopamine or 10(-7) M GR 113808 to GC7101 5 mg mL(-1) decreased the amplitude and area under curve compared to GC7101 5 mg mL(-1) alone. GC7101 accelerated GI transit in a dose dependent manner except 100 mg kg(-1). Delayed GI transit caused by atropine, dop-amine and GR 113808 was restored by GC7101 50 mg kg(-1). CONCLUSIONS: GC7101, an extract of Lonicera Flos, exerts a gastric prokinetic effect in guinea pig through cholinergic, antidopaminergic and serotonergic mechanisms. Therefore, GC7101 might be a novel drug for the treatment of functional dyspepsia.(J Neurogastroenterol Motil 2014;20:469-474).
Files in This Item:
T201403475.pdf Download
DOI
10.5056/jnm14010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
Jeon, Han Ho(전한호)
Jung, Da Hyun(정다현)
Choi, Eun Ju(최은주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99945
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