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Effects of GC7101, a Novel Prokinetic Agent on Gastric Motor Function: Ex Vivo Study

DC FieldValueLanguage
dc.contributor.author박효진-
dc.contributor.author이영호-
dc.contributor.author전한호-
dc.contributor.author정다현-
dc.contributor.author최은주-
dc.date.accessioned2015-01-06T17:25:13Z-
dc.date.available2015-01-06T17:25:13Z-
dc.date.issued2014-
dc.identifier.issn2093-0879-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99945-
dc.description.abstractBACKGROUND/AIMS: GC7101, an extract of Lonicera Flos, is a novel developing drug for reflux esophagitis and functional dyspepsia. However, the drug's exact pharmacological mechanism of action remains unclear. This study assessed the effects of GC7101 on gastro-intestinal (GI) motor function. METHODS: We used male guinea pigs to evaluate the effects of GC7101 on GI motility. The contraction of antral circular muscle in the presence of different doses of GC7101 was measured in a tissue bath. The prokinetic effects of GC7101 were tested using the charcoal transit assay from the pylorus to the most distal point of migration of charcoal mixture. To clarify the mechanism of action of GC7101, atropine, dopamine and the selective 5-hydroxytryptamine 4 receptor antagonist, GR113808 were used. RESULTS: The maximal amplitude of circular muscle contraction was induced by 5 mg mL(-1) GC7101. The area under the curve of con-traction was significantly increased at 5 mg mL(-1) GC7101. Addition of 10(-6) M atropine, 10(-8) M dopamine or 10(-7) M GR 113808 to GC7101 5 mg mL(-1) decreased the amplitude and area under curve compared to GC7101 5 mg mL(-1) alone. GC7101 accelerated GI transit in a dose dependent manner except 100 mg kg(-1). Delayed GI transit caused by atropine, dop-amine and GR 113808 was restored by GC7101 50 mg kg(-1). CONCLUSIONS: GC7101, an extract of Lonicera Flos, exerts a gastric prokinetic effect in guinea pig through cholinergic, antidopaminergic and serotonergic mechanisms. Therefore, GC7101 might be a novel drug for the treatment of functional dyspepsia.(J Neurogastroenterol Motil 2014;20:469-474).-
dc.description.statementOfResponsibilityopen-
dc.format.extent469~474-
dc.relation.isPartOfJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of GC7101, a Novel Prokinetic Agent on Gastric Motor Function: Ex Vivo Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorEun Ju Choi-
dc.contributor.googleauthorHan Ho Jeon-
dc.contributor.googleauthorYoung Ho Lee-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.5056/jnm14010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01774-
dc.contributor.localIdA02968-
dc.contributor.localIdA03559-
dc.contributor.localIdA03591-
dc.contributor.localIdA04160-
dc.relation.journalcodeJ01623-
dc.identifier.eissn2093-0887-
dc.identifier.pmid25273117-
dc.subject.keywordFunctional dyspepsia-
dc.subject.keywordGastrointestinal motility-
dc.subject.keywordLonicera Flos-
dc.subject.keywordProkinetic-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameLee, Young Ho-
dc.contributor.alternativeNameJeon, Han Ho-
dc.contributor.alternativeNameJung, Da Hyun-
dc.contributor.alternativeNameChoi, Eun Ju-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorLee, Young Ho-
dc.contributor.affiliatedAuthorJeon, Han Ho-
dc.contributor.affiliatedAuthorJung, Da Hyun-
dc.contributor.affiliatedAuthorChoi, Eun Ju-
dc.citation.volume20-
dc.citation.number4-
dc.citation.startPage469-
dc.citation.endPage474-
dc.identifier.bibliographicCitationJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.20(4) : 469-474, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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