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Expression of serine and glycine-related enzymes in phyllodes tumor.

Authors
 J. E. KWON  ;  D. H. KIM  ;  W.-H. JUNG  ;  J. S. KOO 
Citation
 NEOPLASMA, Vol.61(5) : 566-78, 2014 
Journal Title
 NEOPLASMA 
ISSN
 0028-2685 
Issue Date
2014
MeSH
Adult ; Breast Neoplasms/metabolism* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Female ; Glycine/metabolism* ; Humans ; Middle Aged ; Phyllodes Tumor/metabolism* ; Phyllodes Tumor/mortality ; Phyllodes Tumor/pathology ; Serine/metabolism*
Keywords
glycine ; tumor grade ; metabolism ; phyllodes tumor ; serine
Abstract
Expression patterns of proteins involved in serine and glycine metabolism, and correlations of these patterns with clinicopathologic factors in phyllodes tumor were investigated. Tissue microarrays were prepared from 203 phyllodes tumors (PT) and stained with antibodies specific for glycine decarboxylase (GLDC), phosphoserine aminotransferase 1 (PSAT1), phosphoserine phosphatase (PSPH), phosphoglycerate dehydrogenase (PHGDH), and serine hydroxymethyltransferase 1 (SHMT1). These immunohistochemical results and clinicopathologic parameters were analyzed for correlation. Numbers of benign, borderline, and malignant tumors were 155, 32, and 16, respectively. Stromal expression of PHGDH, PSAT1, PSPH, SHMT1, and GLDC increased with increasing tumor grade, and epithelial expression of SHMT1 also increased with increasing tumor grade (p<0.001, and p=0.005, respectively). On univariate analysis, positive stainings for stromal PHGDH (p<0.001), stromal PSAT1 (p<0.001), stromal PSPH (p=0.003), epithelial SHMT1 (p=0.001), stromal SHMT1 (p=0.022), and stromal GLDC (p<0.001) were each associated with shorter disease-free survival. Stromal GLDC was associated with shorter overall survival (p<0.001). In conclusion, expression of proteins related to serine and glycine metabolism increased with increasing histologic grade in stromal components of phyllodes tumor.
Full Text
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DOI
10.4149/neo_2014_069
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Do Hee(김도희)
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99902
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