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MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma

DC Field Value Language
dc.contributor.author김세훈-
dc.contributor.author송호택-
dc.contributor.author이다혜-
dc.contributor.author임범진-
dc.contributor.author형우진-
dc.date.accessioned2015-01-06T17:22:54Z-
dc.date.available2015-01-06T17:22:54Z-
dc.date.issued2014-
dc.identifier.issn1019-6439-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99873-
dc.description.abstractAlthough the incidence of brain metastasis in gastric cancer is relatively low, its prevalence may increase with improved therapy and longer survival tumors. The molecular mechanisms underlying brain metastases are not well understood. To gain insight into the mechanism of brain metastasis, we studied differences in microRNA (miRNA) expression levels in 8 cases of matched primary gastric adenocarcinoma and brain metastatic adenocarcinoma using the Illumina microRNA microarray chip. We identified 6 upregulated and 2 downregulated miRNAs in all 8 cases simultaneously. Interestingly, 2 out of 8 miRNAs (hsa-miR‑141-3p and hsa-miR-200b-3p) belonged to the miR-200 family. Online microRNA database searching revealed that ZEB2 is the top-ranked target gene for hsa-miR141-3p and hsa-miR-200b-3p, prompting us to focus ZEB2 expression in brain metastatic adenocarcinoma. We confirmed that ZEB2 expression was markedly downregulated in some brain metastatic samples. In addition, decreased ZEB2 expression was noted by western blot analysis of 2 metastatic gastric adenocarcinoma cell types that were derived by in vivo selection following intracardiac injection of gastric cancer cell lines. In conclusion, we demonstrate that expression of miRNA-200 family members and ZEB2 are associated with brain metastases of gastric adenocarcinoma, not only in matched patient samples, but also in metastatic cell lines that were derived by in vivo selection.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2403~2410-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAnimals-
dc.subject.MESHBrain Neoplasms/genetics*-
dc.subject.MESHBrain Neoplasms/pathology-
dc.subject.MESHBrain Neoplasms/secondary-
dc.subject.MESHCell Proliferation/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHomeodomain Proteins/biosynthesis*-
dc.subject.MESHHomeodomain Proteins/genetics-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMicroRNAs/biosynthesis*-
dc.subject.MESHMicroRNAs/genetics-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHRepressor Proteins/biosynthesis*-
dc.subject.MESHRepressor Proteins/genetics-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHZinc Finger E-box Binding Homeobox 2-
dc.titleMicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorYang-Ki Minn-
dc.contributor.googleauthorDa Hye Lee-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorJi Eun Kim-
dc.contributor.googleauthorJunjeong Choi-
dc.contributor.googleauthorSeung-Ho Yang-
dc.contributor.googleauthorHotaek Song-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorSe Hoon Kim-
dc.identifier.doi10.3892/ijo.2014.2680-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00610-
dc.contributor.localIdA02080-
dc.contributor.localIdA02710-
dc.contributor.localIdA03363-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ01141-
dc.identifier.eissn1791-2423-
dc.identifier.pmid25270520-
dc.identifier.urlhttp://www.spandidos-publications.com/ijo/45/6/2403-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.alternativeNameLee, Da Hye-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.contributor.affiliatedAuthorLee, Da Hye-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.rights.accessRightsfree-
dc.citation.volume45-
dc.citation.number6-
dc.citation.startPage2403-
dc.citation.endPage2410-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ONCOLOGY, Vol.45(6) : 2403-2410, 2014-
dc.identifier.rimsid53851-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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