Cited 15 times in
Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-01-06T17:22:52Z | - |
dc.date.available | 2015-01-06T17:22:52Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99872 | - |
dc.description.abstract | Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 943~952 | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Dextrans/chemistry | - |
dc.subject.MESH | Fluorescence | - |
dc.subject.MESH | Hydrodynamics | - |
dc.subject.MESH | Macrophages/ultrastructure | - |
dc.subject.MESH | Magnetic Resonance Imaging* | - |
dc.subject.MESH | Magnetite Nanoparticles/chemistry* | - |
dc.subject.MESH | Magnetite Nanoparticles/ultrastructure | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nanotechnology/methods* | - |
dc.subject.MESH | Oleic Acid/chemistry | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Plaque, Atherosclerotic/diagnosis* | - |
dc.subject.MESH | Polymers/chemistry* | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Thermogravimetry | - |
dc.subject.MESH | X-Ray Diffraction | - |
dc.title | Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Myeong-Hoon Kim | - |
dc.contributor.googleauthor | Bongjune Kim | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Eunjung Kim | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Hyo Seon Park | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1002/mabi.201400029 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02176 | - |
dc.identifier.eissn | 1616-5195 | - |
dc.identifier.pmid | 24740644 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400029/abstract | - |
dc.subject.keyword | atherosclerotic plaque | - |
dc.subject.keyword | dextran | - |
dc.subject.keyword | imaging | - |
dc.subject.keyword | magnetic nanoclusters | - |
dc.subject.keyword | self-assembly | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 943 | - |
dc.citation.endPage | 952 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, Vol.14(7) : 943-952, 2014 | - |
dc.identifier.rimsid | 53850 | - |
dc.type.rims | ART | - |
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