2 771

Cited 39 times in

MicroRNA-365 Inhibits the Proliferation of Vascular Smooth Muscle Cells by Targeting Cyclin D1

DC Field Value Language
dc.contributor.author함온주-
dc.contributor.author황기철-
dc.contributor.author김명현-
dc.contributor.author민필기-
dc.contributor.author박준희-
dc.contributor.author서향희-
dc.contributor.author이세연-
dc.contributor.author이창연-
dc.contributor.author최은미-
dc.contributor.author최은현-
dc.date.accessioned2015-01-06T17:21:25Z-
dc.date.available2015-01-06T17:21:25Z-
dc.date.issued2014-
dc.identifier.issn0730-2312-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99826-
dc.description.abstractAbnormal proliferation of vascular smooth muscle cells (VSMCs) is a common feature of disease progression in atherosclerosis. Cell proliferation is regulated by cell cycle regulatory proteins. MicroRNAs (miR) have been reported to act as important gene regulators and play essential roles in the proliferation and migration of VSMCs in a cardiovascular disease. However, the roles and mechanisms of miRs in VSMCs and neointimal formation are far from being fully understood. In this study, cell cycle-specific cyclin D1 was found to be a potential target of miR-365 by direct binding. Through an in vitro experiment, we showed that exogenous miR-365 overexpression reduced VSMC proliferation and proliferating cell nuclear antigen (PCNA) expression, while miR-365 was observed to block G1/S transition in platelet-derived growth factor-bb (PDGF-bb)-induced VSMCs. In addition, the proliferation of VSMCs by various stimuli, including PDGF-bb, angiotensin II (Ang II), and serum, led to the downregulation of miR-365 expression levels. The expression of miR-365 was confirmed in balloon-injured carotid arteries. Taken together, our results suggest an anti-proliferative role for miR-365 in VSMC proliferation, at least partly via modulating the expression of cyclin D1. Therefore, miR-365 may influence neointimal formation in atherosclerosis patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1752~1761-
dc.relation.isPartOfJOURNAL OF CELLULAR BIOCHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAngiotensin II/pharmacology-
dc.subject.MESHAnimals-
dc.subject.MESHAtherosclerosis/pathology*-
dc.subject.MESHCarotid Arteries/metabolism-
dc.subject.MESHCarotid Artery Injuries/metabolism-
dc.subject.MESHCell Division/genetics-
dc.subject.MESHCell Movement/genetics-
dc.subject.MESHCell Proliferation/genetics-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCyclin D1/biosynthesis*-
dc.subject.MESHDown-Regulation-
dc.subject.MESHMicroRNAs/biosynthesis-
dc.subject.MESHMicroRNAs/genetics*-
dc.subject.MESHMuscle, Smooth, Vascular/cytology-
dc.subject.MESHMuscle, Smooth, Vascular/growth & development*-
dc.subject.MESHNeointima/genetics*-
dc.subject.MESHProliferating Cell Nuclear Antigen/biosynthesis-
dc.subject.MESHProtein Binding-
dc.subject.MESHProto-Oncogene Proteins c-sis/pharmacology-
dc.subject.MESHRNA-Binding Proteins-
dc.subject.MESHRats-
dc.subject.MESHS Phase Cell Cycle Checkpoints/genetics-
dc.titleMicroRNA-365 Inhibits the Proliferation of Vascular Smooth Muscle Cells by Targeting Cyclin D1-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentYonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)-
dc.contributor.googleauthorMyung-Hyun Kim-
dc.contributor.googleauthorOnju Ham-
dc.contributor.googleauthorSe-Yeon Lee-
dc.contributor.googleauthorEunmi Choi-
dc.contributor.googleauthorChang Youn Lee-
dc.contributor.googleauthorJun-Hee Park-
dc.contributor.googleauthorJiyun Lee-
dc.contributor.googleauthorHyang-Hee Seo-
dc.contributor.googleauthorMinji Seung-
dc.contributor.googleauthorEunhyun Choi-
dc.contributor.googleauthorPil-Ki Min-
dc.contributor.googleauthorKi-Chul Hwang-
dc.identifier.doi10.1002/jcb.24841-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04336-
dc.contributor.localIdA04456-
dc.contributor.localIdA01412-
dc.contributor.localIdA01679-
dc.contributor.localIdA01921-
dc.contributor.localIdA02880-
dc.contributor.localIdA03244-
dc.contributor.localIdA04162-
dc.contributor.localIdA04151-
dc.contributor.localIdA00427-
dc.relation.journalcodeJ01303-
dc.identifier.eissn1097-4644-
dc.identifier.pmid24819721-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jcb.24841/abstract-
dc.subject.keywordCELL CYCLE-
dc.subject.keywordCYCLIN D1-
dc.subject.keywordMIR-365-
dc.subject.keywordPROLIFERATION-
dc.subject.keywordVASCULAR SMOOTH MUSCLE CELLS-
dc.contributor.alternativeNameHam, On Ju-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.alternativeNameKim, Myung Hyun-
dc.contributor.alternativeNameMin, Pil Ki-
dc.contributor.alternativeNamePark, Jun-Hee-
dc.contributor.alternativeNameSeo, Hyang Hee-
dc.contributor.alternativeNameLee, Se Yeon-
dc.contributor.alternativeNameLee, Chang Yeon-
dc.contributor.alternativeNameChoi, Eun Mi-
dc.contributor.alternativeNameChoi, Eun Hyun-
dc.contributor.affiliatedAuthorHam, On Ju-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.contributor.affiliatedAuthorMin, Pil Ki-
dc.contributor.affiliatedAuthorPark, Jun-Hee-
dc.contributor.affiliatedAuthorSeo, Hyang Hee-
dc.contributor.affiliatedAuthorLee, Se Yeon-
dc.contributor.affiliatedAuthorLee, Chang Yeon-
dc.contributor.affiliatedAuthorChoi, Eun Hyun-
dc.contributor.affiliatedAuthorChoi, Eun Mi-
dc.contributor.affiliatedAuthorKim, Myung Hyun-
dc.rights.accessRightsfree-
dc.citation.volume115-
dc.citation.number10-
dc.citation.startPage1752-
dc.citation.endPage1761-
dc.identifier.bibliographicCitationJOURNAL OF CELLULAR BIOCHEMISTRY, Vol.115(10) : 1752-1761, 2014-
dc.identifier.rimsid49628-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.