178 289

Cited 7 times in

The Role of Insulin Resistance in Diabetic Neuropathy in Koreans with Type 2 Diabetes Mellitus: A 6-Year Follow-Up Study

 Yu Na Cho  ;  Kee Ook Lee  ;  Julie Jeong  ;  Hyung Jun Park  ;  Seung-Min Kim  ;  Ha Young Shin  ;  Ji-Man Hong  ;  Chul Woo Ahn  ;  Young-Chul Choi 
 YONSEI MEDICAL JOURNAL, Vol.55(3) : 700-708, 2014 
Journal Title
Issue Date
Adult ; Diabetes Mellitus, Type 2/metabolism* ; Diabetes Mellitus, Type 2/physiopathology* ; Diabetic Neuropathies/metabolism* ; Diabetic Neuropathies/physiopathology* ; Female ; Humans ; Insulin Resistance/physiology* ; Logistic Models ; Male ; Middle Aged
Insulin resistance ; diabetic neuropathy ; metabolic syndrome ; type 2 diabetes mellitus
PURPOSE: We previously reported that insulin resistance, low high-density lipoprotein (HDL) cholesterol, and glycaemic exposure Index are independently associated with peripheral neuropathy in Korean patients with type 2 diabetes mellitus. We followed the patients who participated in that study in 2006 for another 6 years to determine the relationship between insulin resistance and neuropathy. MATERIALS AND METHODS: This study involved 48 of the original 86 Korean patients with type 2 diabetes mellitus who were referred to the Neurology clinic for the assessment of diabetic neuropathy from January 2006 to December 2006. These 48 patients received management for glycaemic control and prevention of diabetic complications in the outpatient clinic up to 2012. We reviewed blood test results and the nerve conduction study findings of these patients, taken over a 6-year period. RESULTS: Low HDL cholesterol and high triglycerides significantly influenced the development of diabetic neuropathy. Kitt value (1/insulin resistance) in the previous study affected the occurrence of neuropathy, despite adequate glycaemic control with HbA1c <7%. Insulin resistance affected the development of diabetic neuropathy after 6 years: insulin resistance in 2006 showed a positive correlation with a change in sural sensory nerve action potential in 2012. CONCLUSION: Diabetic neuropathy can be affected by previous insulin resistance despite regular glycaemic control. Dyslipidaemia should be controlled in patients who show high insulin resistance because HDL cholesterol and triglycerides are strongly correlated with later development of diabetic neuropathy.
Files in This Item:
T201403230.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Cho, Yu Na(조유나)
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
Hong, Ji Man(홍지만) ORCID logo https://orcid.org/0000-0002-0696-8448
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.