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High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients

 Ha-young Lee  ;  Joong Bae Ahn  ;  Sun Young Rha  ;  Hyun Cheol Chung  ;  Kyu Hyun Park  ;  Tae Soo Kim  ;  Nam Kyu Kim  ;  Sang Joon Shin 
 World Journal of Surgical Oncology, Vol.12 : 232-238, 2014 
Journal Title
 World Journal of Surgical Oncology 
Issue Date
Adenocarcinoma, Mucinous/metabolism ; Adenocarcinoma, Mucinous/mortality* ; Adenocarcinoma, Mucinous/secondary ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Colon/metabolism* ; Colon/pathology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/mortality* ; Colorectal Neoplasms/pathology ; Female ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/mortality* ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Prognosis ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Rectum/metabolism* ; Rectum/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Rate
KLF4 ; Prognostic marker ; Colorectal cancer
BACKGROUND: Krüppel-like factor 4 (KLF4) is involved in many important cellular processes such as growth, development, differentiation, proliferation, and apoptosis. The purpose of this study was to determine the significance of KLF4 in both tumors and normal tissues of patients with colorectal cancer (CRC). METHODS: Between January 2003 and June 2005, 125 patients with CRC receiving treatment at the Yonsei Cancer Center were selected. We examined the mRNA level of the KLF4 gene in primary CRC specimens and matched normal colon tissues using real-time RT-PCR. Correlation of survival with clinicopathological parameters, including KLF4 level, was investigated with univariate and multivariate analyses. RESULTS: CRC tissue had a significantly lower KLF4 level when compared with matched normal tissues (KLF4 in tumors: 2007 ± 1531 copies/μl, KLF4 in normal tissues: 6586 ± 2834 copies/μl; P < 0.0001). However, there was a correlation between the KLF4 level in tumors and normal tissues. Patients with a high KLF4 level in matched normal tissues were more likely than those with a low KLF4 level to develop recurrence and had poorer overall survival (P = 0.005). Therefore, the KLF4 level in the normal tissue of individuals was associated with prognosis of individuals. CONCLUSIONS: Our data suggest that KLF4 mRNA expression level in normal tissues and tumors may be a useful prognostic marker in patients with CRC.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
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