Cited 32 times in
High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김남규 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2015-01-06T17:20:17Z | - |
dc.date.available | 2015-01-06T17:20:17Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99791 | - |
dc.description.abstract | BACKGROUND: Krüppel-like factor 4 (KLF4) is involved in many important cellular processes such as growth, development, differentiation, proliferation, and apoptosis. The purpose of this study was to determine the significance of KLF4 in both tumors and normal tissues of patients with colorectal cancer (CRC). METHODS: Between January 2003 and June 2005, 125 patients with CRC receiving treatment at the Yonsei Cancer Center were selected. We examined the mRNA level of the KLF4 gene in primary CRC specimens and matched normal colon tissues using real-time RT-PCR. Correlation of survival with clinicopathological parameters, including KLF4 level, was investigated with univariate and multivariate analyses. RESULTS: CRC tissue had a significantly lower KLF4 level when compared with matched normal tissues (KLF4 in tumors: 2007 ± 1531 copies/μl, KLF4 in normal tissues: 6586 ± 2834 copies/μl; P < 0.0001). However, there was a correlation between the KLF4 level in tumors and normal tissues. Patients with a high KLF4 level in matched normal tissues were more likely than those with a low KLF4 level to develop recurrence and had poorer overall survival (P = 0.005). Therefore, the KLF4 level in the normal tissue of individuals was associated with prognosis of individuals. CONCLUSIONS: Our data suggest that KLF4 mRNA expression level in normal tissues and tumors may be a useful prognostic marker in patients with CRC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 232~238 | - |
dc.relation.isPartOf | WORLD JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/metabolism | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/mortality* | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/secondary | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Colon/metabolism* | - |
dc.subject.MESH | Colon/pathology | - |
dc.subject.MESH | Colorectal Neoplasms/metabolism | - |
dc.subject.MESH | Colorectal Neoplasms/mortality* | - |
dc.subject.MESH | Colorectal Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Kruppel-Like Transcription Factors/genetics | - |
dc.subject.MESH | Kruppel-Like Transcription Factors/metabolism* | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Recurrence, Local/metabolism | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Rectum/metabolism* | - |
dc.subject.MESH | Rectum/pathology | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Survival Rate | - |
dc.title | High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ha-young Lee | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Kyu Hyun Park | - |
dc.contributor.googleauthor | Tae Soo Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.identifier.doi | 10.1186/1477-7819-12-232 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02803 | - |
dc.identifier.eissn | 1477-7819 | - |
dc.identifier.pmid | 25060774 | - |
dc.subject.keyword | KLF4 | - |
dc.subject.keyword | Prognostic marker | - |
dc.subject.keyword | Colorectal cancer | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 232 | - |
dc.citation.endPage | 238 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF SURGICAL ONCOLOGY, Vol.12 : 232-238, 2014 | - |
dc.identifier.rimsid | 49601 | - |
dc.type.rims | ART | - |
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