148 203

Cited 5 times in

Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response

Authors
 Su Jung Lee  ;  Sung Jae Shin  ;  Seung Jun Lee  ;  Moon Hee Lee  ;  Tae Heung Kang  ;  Kyung Tae Noh  ;  Yong Kyoo Shin  ;  Han Wool Kim  ;  Cheol-Heui Yun  ;  In Duk Jung  ;  Yeong-Min Park 
Citation
 BMB REPORTS, Vol.47(9) : 512-517, 2014 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2014
MeSH
Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism* ; Bacterial Proteins/pharmacology ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Cells, Cultured ; Dendritic Cells/cytology* ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Female ; Interleukin-12/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Inbred C57BL ; Mycobacterium/metabolism* ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/pharmacology ; Th1 Cells/drug effects ; Th1 Cells/immunology* ; Th1 Cells/metabolism ; Toll-Like Receptor 4/metabolism* ; Tumor Necrosis Factor-alpha/metabolism
Keywords
Dendritic cells ; MAB2560 ; MAPKs ; Mycobacterium abscessus ; Th1 polarization
Abstract
In this study, we showed that Mycobacterium abscessus MAB2560 induces the maturation of dendritic cells (DCs), which are representative antigen-presenting cells (APCs). M. abscessus MAB2560 stimulate the production of pro-inflammatory cytokines [interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, and IL-12p70] and reduce the endocytic capacity and maturation of DCs. Using TLR4-/- DCs, we found that MAB2560 mediated DC maturation via Toll-like receptor 4 (TLR4). MAB2560 also activated the MAPK signaling pathway, which was essential for DC maturation. Furthermore, MAB2560- treated DCs induced the transformation of naïve T cells to polarized CD4+ and CD8+ T cells, which would be crucial for Th1 polarization of the immune response. Taken together, our results indicate that MAB2560 could potentially regulate the host immune response to M. abscessus and may have critical implications for the manipulation of DC functions for developing DC-based immunotherapy.
Files in This Item:
T201403198.pdf Download
DOI
10.5483/BMBRep.2014.47.9.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99789
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links