Cited 14 times in
Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2015-01-06T17:20:13Z | - |
dc.date.available | 2015-01-06T17:20:13Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99789 | - |
dc.description.abstract | In this study, we showed that Mycobacterium abscessus MAB2560 induces the maturation of dendritic cells (DCs), which are representative antigen-presenting cells (APCs). M. abscessus MAB2560 stimulate the production of pro-inflammatory cytokines [interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, and IL-12p70] and reduce the endocytic capacity and maturation of DCs. Using TLR4-/- DCs, we found that MAB2560 mediated DC maturation via Toll-like receptor 4 (TLR4). MAB2560 also activated the MAPK signaling pathway, which was essential for DC maturation. Furthermore, MAB2560- treated DCs induced the transformation of naïve T cells to polarized CD4+ and CD8+ T cells, which would be crucial for Th1 polarization of the immune response. Taken together, our results indicate that MAB2560 could potentially regulate the host immune response to M. abscessus and may have critical implications for the manipulation of DC functions for developing DC-based immunotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | Bacterial Proteins/metabolism* | - |
dc.subject.MESH | Bacterial Proteins/pharmacology | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/cytology | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/cytology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dendritic Cells/cytology* | - |
dc.subject.MESH | Dendritic Cells/drug effects | - |
dc.subject.MESH | Dendritic Cells/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Interleukin-12/metabolism | - |
dc.subject.MESH | Interleukin-1beta/metabolism | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mycobacterium/metabolism* | - |
dc.subject.MESH | Recombinant Proteins/biosynthesis | - |
dc.subject.MESH | Recombinant Proteins/genetics | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Th1 Cells/drug effects | - |
dc.subject.MESH | Th1 Cells/immunology* | - |
dc.subject.MESH | Th1 Cells/metabolism | - |
dc.subject.MESH | Toll-Like Receptor 4/metabolism* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.title | Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Su Jung Lee | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Seung Jun Lee | - |
dc.contributor.googleauthor | Moon Hee Lee | - |
dc.contributor.googleauthor | Tae Heung Kang | - |
dc.contributor.googleauthor | Kyung Tae Noh | - |
dc.contributor.googleauthor | Yong Kyoo Shin | - |
dc.contributor.googleauthor | Han Wool Kim | - |
dc.contributor.googleauthor | Cheol-Heui Yun | - |
dc.contributor.googleauthor | In Duk Jung | - |
dc.contributor.googleauthor | Yeong-Min Park | - |
dc.identifier.doi | 10.5483/BMBRep.2014.47.9.001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02113 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.identifier.pmid | 24667171 | - |
dc.subject.keyword | Dendritic cells | - |
dc.subject.keyword | MAB2560 | - |
dc.subject.keyword | MAPKs | - |
dc.subject.keyword | Mycobacterium abscessus | - |
dc.subject.keyword | Th1 polarization | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 47 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 512 | - |
dc.citation.endPage | 517 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.47(9) : 512-517, 2014 | - |
dc.identifier.rimsid | 49599 | - |
dc.type.rims | ART | - |
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