265 502

Cited 14 times in

Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response

DC Field Value Language
dc.contributor.author신성재-
dc.date.accessioned2015-01-06T17:20:13Z-
dc.date.available2015-01-06T17:20:13Z-
dc.date.issued2014-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99789-
dc.description.abstractIn this study, we showed that Mycobacterium abscessus MAB2560 induces the maturation of dendritic cells (DCs), which are representative antigen-presenting cells (APCs). M. abscessus MAB2560 stimulate the production of pro-inflammatory cytokines [interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, and IL-12p70] and reduce the endocytic capacity and maturation of DCs. Using TLR4-/- DCs, we found that MAB2560 mediated DC maturation via Toll-like receptor 4 (TLR4). MAB2560 also activated the MAPK signaling pathway, which was essential for DC maturation. Furthermore, MAB2560- treated DCs induced the transformation of naïve T cells to polarized CD4+ and CD8+ T cells, which would be crucial for Th1 polarization of the immune response. Taken together, our results indicate that MAB2560 could potentially regulate the host immune response to M. abscessus and may have critical implications for the manipulation of DC functions for developing DC-based immunotherapy.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfBMB REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBacterial Proteins/genetics-
dc.subject.MESHBacterial Proteins/metabolism*-
dc.subject.MESHBacterial Proteins/pharmacology-
dc.subject.MESHCD4-Positive T-Lymphocytes/cytology-
dc.subject.MESHCD4-Positive T-Lymphocytes/immunology-
dc.subject.MESHCD8-Positive T-Lymphocytes/cytology-
dc.subject.MESHCD8-Positive T-Lymphocytes/immunology-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDendritic Cells/cytology*-
dc.subject.MESHDendritic Cells/drug effects-
dc.subject.MESHDendritic Cells/immunology-
dc.subject.MESHFemale-
dc.subject.MESHInterleukin-12/metabolism-
dc.subject.MESHInterleukin-1beta/metabolism-
dc.subject.MESHInterleukin-6/metabolism-
dc.subject.MESHMAP Kinase Signaling System-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMycobacterium/metabolism*-
dc.subject.MESHRecombinant Proteins/biosynthesis-
dc.subject.MESHRecombinant Proteins/genetics-
dc.subject.MESHRecombinant Proteins/pharmacology-
dc.subject.MESHTh1 Cells/drug effects-
dc.subject.MESHTh1 Cells/immunology*-
dc.subject.MESHTh1 Cells/metabolism-
dc.subject.MESHToll-Like Receptor 4/metabolism*-
dc.subject.MESHTumor Necrosis Factor-alpha/metabolism-
dc.titleMycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSu Jung Lee-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorSeung Jun Lee-
dc.contributor.googleauthorMoon Hee Lee-
dc.contributor.googleauthorTae Heung Kang-
dc.contributor.googleauthorKyung Tae Noh-
dc.contributor.googleauthorYong Kyoo Shin-
dc.contributor.googleauthorHan Wool Kim-
dc.contributor.googleauthorCheol-Heui Yun-
dc.contributor.googleauthorIn Duk Jung-
dc.contributor.googleauthorYeong-Min Park-
dc.identifier.doi10.5483/BMBRep.2014.47.9.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02113-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid24667171-
dc.subject.keywordDendritic cells-
dc.subject.keywordMAB2560-
dc.subject.keywordMAPKs-
dc.subject.keywordMycobacterium abscessus-
dc.subject.keywordTh1 polarization-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthorShin, Sung Jae-
dc.citation.volume47-
dc.citation.number9-
dc.citation.startPage512-
dc.citation.endPage517-
dc.identifier.bibliographicCitationBMB REPORTS, Vol.47(9) : 512-517, 2014-
dc.identifier.rimsid49599-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.