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Kinematic Analysis in Patients with Parkinson’s Disease and SWEDD

Authors
 Myung Jun Lee  ;  Sha Lom Kim  ;  Chul Hyoung Lyoo  ;  Myung Sik Lee 
Citation
 JOURNAL OF PARKINSONS DISEASE, Vol.4(3) : 421-430, 2014 
Journal Title
 JOURNAL OF PARKINSONS DISEASE 
ISSN
 1877-7171 
Issue Date
2014
MeSH
Aged ; Biomechanical Phenomena ; Diagnosis, Differential ; Female ; Fingers ; Humans ; Male ; Middle Aged ; Motor Activity* ; Parkinson Disease/diagnosis* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/physiopathology* ; Positron-Emission Tomography
Keywords
Parkinson's disease ; SWEDD ; finger tapping ; kinematic analysis
Abstract
BACKGROUND AND OBJECTIVES: The differential diagnosis between mild Parkinson's disease (PD) and Scan Without Evidence of Dopaminergic Deficit(SWEDD) is challenging. Progressive reduction in amplitude and speed of finger tapping (sequence effect) has been considered as the most useful sign for discriminating PD from SWEDD. However, a video analysis reported that sequence effect is a major confounding factor for the misdiagnosis of PD. Our objective was to perform a kinematic analysis of finger tapping to explore parameters for distinguishing between patients with PD and SWEDD. METHODS: We enrolled 14 patients with PD, 17 patients with SWEDD and 18 age- and sex-matched healthy controls. Amplitude, speed and frequency of finger tapping were measured using gyroscopes, and the means, decrement and variability in kinematic parameters for specific tapping duration were calculated. RESULTS: Compared to SWEDD group, PD group showed more decrement in amplitude and speed of the first 20 taps, more decrement in frequency after 20 taps and more variability in speed of 15 seconds of taps. However, none of parameters was a practically useful indicator distinguishing individual patients with PD from those with SWEDD. CONCLUSIONS: Analysis of finger tapping, even using an apparatus, is not useful for distinguishing mild PD and SWEDD.
Full Text
http://iospress.metapress.com/content/783n414484203023/?issue=3&genre=article&spage=421&issn=1877-7171&volume=4
DOI
10.3233/JPD-130233
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sha Lom(김샤롬)
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Myung Jun(이명준)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99687
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