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Can increased tumoral vascularity be a quantitative predicting factor of lymph node metastasis in papillary thyroid microcarcinoma?

Authors
 Hyun Joo Shin  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Kyung Hwa Han  ;  Jin Young Kwak 
Citation
 ENDOCRINE, Vol.47(1) : 273-282, 2014 
Journal Title
 ENDOCRINE 
ISSN
 1355-008X 
Issue Date
2014
MeSH
Adult ; Aged ; Carcinoma/blood supply* ; Carcinoma/diagnosis* ; Carcinoma/pathology* ; Carcinoma/surgery ; Carcinoma, Papillary ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neovascularization, Pathologic/diagnosis* ; Prognosis ; Retrospective Studies ; Thyroid Neoplasms/blood supply* ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery ; Thyroidectomy ; Tumor Burden ; Young Adult
Keywords
Thyroid ; Ultrasound ; Papillary thyroid microcarcinoma ; Vascularity
Abstract
The aim of the present study was to evaluate the clinical implications of the vascular index (VI) as a predicting factor for central and lateral lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). From January 2011 to October 2011, 588 patients (495 females, 93 males) who were diagnosed with PTMC were included. Clinicopathologic characteristics of patients and ultrasound (US) features of the lesions including VI were evaluated retrospectively. The VI was measured with QLAB 7.0 quantification software using preoperative Doppler US images. Univariate and multivariate analysis were used to assess predictive factors of LNM. From 588 patients, 140 patients (23.8 %) had central LNM and 26 patients (4.4 %) had lateral LNM on pathologic results. The presence of lateral LNM [odds ratio (OR) 5.46; 95 % confidence interval (CI) = 2.19–13.64], bilaterality (OR 2.16; 95 % CI 1.17–4.01), and increased tumor size (OR 1.15; 95 % CI 1.04–1.28) were significant independent factors for predicting central LNM. The presence of central LNM (OR 5.58; 95 % CI 2.22–14.04), upper third location of malignancy (OR 2.50; 95 % CI 1.01–6.21), and tumor size (OR 1.34; 95 % CI 1.03–1.73) were significant independent factors for predicting lateral LNM. However, the VI was not a significant predicting factor for both central and lateral LNM. Therefore, the VI of PTMC may not be useful for predicting central and lateral LNM in patients with PTMC.
Full Text
http://link.springer.com/article/10.1007%2Fs12020-013-0131-8
DOI
10.1007/s12020-013-0131-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Shin, Hyun Joo(신현주) ORCID logo https://orcid.org/0000-0002-7462-2609
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99619
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