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Renal Function Is Associated with Bone Mineral Density and Arterial Stiffness in Healthy Postmenopausal Women

Authors
 Jung Y.S.  ;  Hwang H.  ;  Yun B.H.  ;  Chon S.J.  ;  Cho S.  ;  Choi Y.S.  ;  Kim Y.T.  ;  Lee B.S.  ;  Seo S.K. 
Citation
 GYNECOLOGIC AND OBSTETRIC INVESTIGATION, Vol.78(2) : 124-129, 2014 
Journal Title
 GYNECOLOGIC AND OBSTETRIC INVESTIGATION 
ISSN
 0378-7346 
Issue Date
2014
MeSH
Aged ; Aging ; Body Mass Index ; Bone Density/physiology* ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Follicle Stimulating Hormone/blood ; Glomerular Filtration Rate ; Humans ; Kidney/physiology* ; Middle Aged ; Postmenopause/physiology* ; Retrospective Studies ; Thyrotropin/blood ; Vascular Stiffness/physiology*
Keywords
Renal function ; Bone mineral density ; Arterial stiffness ; Postmenopausal women
Abstract
Background/Aims: This study aimed to investigate the effect of renal function on bone mineral density (BMD) and arterial stiffness in postmenopausal women. Methods: This is a retrospective cross-sectional study. We studied 252 postmenopausal women who visited a health promotion center for a medical checkup. The estimated glomerular filtration rate (eGFR) was calculated using the Cockcroft-Gault (CG) formula and the modification of diet in renal disease (MDRD) formula. Areal BMD measurements were performed using dual-energy X-ray absorptiometry, and arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: The eGFR according to the CG formula was significantly correlated with age, BMI, follicle-stimulating hormone, thyroid-stimulating hormone, high-density lipoprotein cholesterol, baPWV, and BMD at the lumbar spine, femoral neck, and total hip sites. However, the eGFR according to the MDRD formula was significantly correlated with age and baPWV but not with BMD at the lumbar spine, femoral neck, and total hip sites. Decreased renal function (eGFR <60 ml/min/1.73 m2 according to the CG formula) was independently associated with decreased BMD at the femoral neck site and with increased baPWV (>1,500 cm/s) after adjusting for confounding variables. Conclusion: Postmenopausal women with decreased renal function are more likely to have a decreased BMD and greater arterial stiffness.
Full Text
http://www.karger.com/Article/FullText/363746
DOI
10.1159/000363746
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Chon, Seung Joo(전승주)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
Hwang, Hee Jin(황희진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99589
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