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Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa: clinical impact of bacterial virulence and strains on outcome

Authors
 Su Jin Jeong  ;  Sang Sun Yoon  ;  Il Kwon Bae  ;  Seok Hoon Jeong  ;  June Myung Kim  ;  Kyungwon Lee 
Citation
 Diagnostic Microbiology and Infectious Disease, Vol.80(2) : 130-135, 2014 
Journal Title
 Diagnostic Microbiology and Infectious Disease 
ISSN
 0732-8893 
Issue Date
2014
Abstract
The incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteremia has increased in recent years, and infections caused by CRPA result in higher mortality than those caused by susceptible strains. This study was performed to evaluate the risk factors for mortality and to study the impact of virulence factors and bacterial strains on clinical outcomes in patients with CRPA bacteremia. Data on 63 episodes of CRPA bacteremia that have occurred between January 1, 2007, and December 31, 2009, in a teaching hospital (2000 beds) in Seoul, Korea, were analyzed. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score at the time of CRPA bacteremia and the capacity of CRPA to form biofilm were independent predictive factors for mortality in patients with CRPA bacteremia. In addition, the biofilm-forming ability and elastase activity of strains were correlated with APACHE II scores to measure the severity of disease and estimate predicted mortality in the patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889314002855
DOI
10.1016/j.diagmicrobio.2014.07.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김준명(Kim, June Myung)
윤상선(Yoon, Sang Sun) ORCID logo https://orcid.org/0000-0003-2979-365X
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99555
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