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Cognitive and cortical thinning patterns of subjective cognitive decline in patients with and without Parkinson's disease

 Jin Yong Hong  ;  Hyuk Jin Yun  ;  Mun Kyung Sunwoo  ;  Jee Hyun Ham  ;  Jong-Min Lee  ;  Young H. Sohn  ;  Phil Hyu Lee 
 PARKINSONISM & RELATED DISORDERS, Vol.20(9) : 999-1003, 2014 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Cerebral Cortex/physiopathology ; Cognition/physiology* ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cognition Disorders/physiopathology ; Cognition Disorders/psychology* ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/psychology* ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Memory/physiology* ; Middle Aged ; Neuropsychological Tests* ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/psychology*
Parkinson's disease ; Semantic fluency ; Subjective cognitive decline ; cortical thickness
BACKGROUND: Subjective cognitive decline (SCD) has gained attention as a predictor of future cognitive decline in neurodegenerative diseases. Based on the hypothesis that different pathologies may distinctly contribute to SCD, we investigated the cognitive profiles and cortical thickness of patients with SCD, with and without Parkinson's disease (PD).
METHODS: In total, 96 patients experiencing SCD were classified as having PD (SCD-PD(+), n = 49) or no neurological disease (SCD-PD(-), n = 47); cognitively normal subjects without SCD (n = 23) were included as controls. Neurocognitive profiles and cortical thickness were examined using standardized neuropsychological tests and magnetic resonance imaging-based analysis.
RESULTS: No significant differences in demographic characteristics were found among the three groups. Neuropsychological tests demonstrated that the SCD-PD(+) patients had lower semantic fluency than SCD-PD(-) patients and controls, and showed poorer performance in visual memory and confrontational naming than controls, whereas no significant difference in cognitive performance was observed between the SCD-PD(-) patients and controls. Cortical thickness analysis revealed that the SCD-PD(+) patients had focal cortical thinning in the dorsolateral prefrontal, orbitofrontal, parietal, and parahippocampal areas compared with controls. Compared with SCD-PD(-) patients, SCD-PD(+) patients had cortical thinning in the frontal, parahippocampal, and posterior cortical areas.
CONCLUSION: Our data show that cortical thinning and cognitive performance in patients with SCD may differ based on the presence of PD, suggesting that SCD in patients with PD reflects disease-related cortical thinning and cognitive dysfunctions more closely than SCD without PD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
Hong, Jin Yong(홍진용)
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