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Cognitive and cortical thinning patterns of subjective cognitive decline in patients with and without Parkinson's disease

DC Field Value Language
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이필휴-
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.date.accessioned2015-01-06T17:12:48Z-
dc.date.available2015-01-06T17:12:48Z-
dc.date.issued2014-
dc.identifier.issn1353-8020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99547-
dc.description.abstractBACKGROUND: Subjective cognitive decline (SCD) has gained attention as a predictor of future cognitive decline in neurodegenerative diseases. Based on the hypothesis that different pathologies may distinctly contribute to SCD, we investigated the cognitive profiles and cortical thickness of patients with SCD, with and without Parkinson's disease (PD). METHODS: In total, 96 patients experiencing SCD were classified as having PD (SCD-PD(+), n = 49) or no neurological disease (SCD-PD(-), n = 47); cognitively normal subjects without SCD (n = 23) were included as controls. Neurocognitive profiles and cortical thickness were examined using standardized neuropsychological tests and magnetic resonance imaging-based analysis. RESULTS: No significant differences in demographic characteristics were found among the three groups. Neuropsychological tests demonstrated that the SCD-PD(+) patients had lower semantic fluency than SCD-PD(-) patients and controls, and showed poorer performance in visual memory and confrontational naming than controls, whereas no significant difference in cognitive performance was observed between the SCD-PD(-) patients and controls. Cortical thickness analysis revealed that the SCD-PD(+) patients had focal cortical thinning in the dorsolateral prefrontal, orbitofrontal, parietal, and parahippocampal areas compared with controls. Compared with SCD-PD(-) patients, SCD-PD(+) patients had cortical thinning in the frontal, parahippocampal, and posterior cortical areas. CONCLUSION: Our data show that cortical thinning and cognitive performance in patients with SCD may differ based on the presence of PD, suggesting that SCD in patients with PD reflects disease-related cortical thinning and cognitive dysfunctions more closely than SCD without PD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent999~1003-
dc.relation.isPartOfPARKINSONISM & RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCerebral Cortex/physiopathology-
dc.subject.MESHCognition/physiology*-
dc.subject.MESHCognition Disorders/diagnosis-
dc.subject.MESHCognition Disorders/etiology-
dc.subject.MESHCognition Disorders/physiopathology-
dc.subject.MESHCognition Disorders/psychology*-
dc.subject.MESHCognitive Dysfunction/diagnosis-
dc.subject.MESHCognitive Dysfunction/physiopathology-
dc.subject.MESHCognitive Dysfunction/psychology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMale-
dc.subject.MESHMemory/physiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests*-
dc.subject.MESHParkinson Disease/complications-
dc.subject.MESHParkinson Disease/diagnosis-
dc.subject.MESHParkinson Disease/psychology*-
dc.titleCognitive and cortical thinning patterns of subjective cognitive decline in patients with and without Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorHyuk Jin Yun-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1016/j.parkreldis.2014.06.011-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.relation.journalcodeJ02468-
dc.identifier.eissn1873-5126-
dc.identifier.pmid25001316-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1353802014002314-
dc.subject.keywordParkinson's disease-
dc.subject.keywordSemantic fluency-
dc.subject.keywordSubjective cognitive decline-
dc.subject.keywordcortical thickness-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.rights.accessRightsfree-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage999-
dc.citation.endPage1003-
dc.identifier.bibliographicCitationPARKINSONISM & RELATED DISORDERS, Vol.20(9) : 999-1003, 2014-
dc.identifier.rimsid39492-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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