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Resveratrol promotes the expression of interleukin-10 and brain-derived neurotrophic factor in microglia under hypoxia.

Authors
 Juhyun Song  ;  So Yeong Cheon  ;  Wonsug Jung  ;  Won Taek Lee  ;  Jong Eun Lee 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.15 : 15512-15529, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2014
MeSH
Animals ; Antioxidants/pharmacology* ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism* ; Cell Hypoxia ; Cell Line ; Interleukin-10/genetics ; Interleukin-10/metabolism* ; Mice ; Microglia/drug effects* ; Microglia/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stilbenes/pharmacology* ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Keywords
resveratrol ; microglia ; hypoxia ; nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) ; interleukin-10 (IL-10) ; brain-derived neurotrophic factor (BDNF)
Abstract
Microglia are the resident macrophages of the central nervous system (CNS) and play an important role in neuronal recovery by scavenging damaged neurons. However, overactivation of microglia leads to neuronal death that is associated with CNS disorders. Therefore, regulation of microglial activation has been suggested to be an important target for treatment of CNS diseases. In the present study, we investigated the beneficial effect of resveratrol, a natural phenol with antioxidant effects, in the microglial cell line, BV2, in a model of hypoxia injury. Resveratrol suppressed the mRNA expression of the pro-inflammatory molecule, tumor necrosis factor-α, and promoted the mRNA expression of the anti-inflammatory molecule, interleukin-10, in BV2 microglia under hypoxic conditions. In addition, resveratrol inhibited the activation of the transcription factor, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), which is upstream in the control of inflammatory reactions in hypoxia-injured BV2 microglia. Moreover, resveratrol promoted the expression of brain-derived neurotrophic factor (BDNF) in BV2 microglia under hypoxic stress. Overall, resveratrol may promote the beneficial function of microglia in ischemic brain injury.
Files in This Item:
T201402704.pdf Download
DOI
10.3390/ijms150915512
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Song, Ju Hyun(송주현)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99509
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